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Chemical Manufacturing Methods for the 21st Century Pharmaceutical Industries

Objective

CHEM21 is a project that will develop a broad based portfolio of sustainable technologies for green chemical intermediate manufacture aimed at the pharmaceutical industry. Initially working with the EFPIA members the collaborators of CHEM21 will analyse a number of projects that are in development to decide which the priorities are for technology development. This analysis will also be used to update the literature of green technology based on updating previous papers.
The technology being developed is divided into three work packages based on chemical catalysis and synthetic methods, biocatalysis and synthetic biology. The first effort will investigate the use of a range of catalysts with a main focus on replacing and applying catalysts based on common metals rather than the precious metal based catalysts that have limitations of sustainable supply. Use of continuous reactors and process intensification will also be addressed as well as fluorination chemistry. In biocatalysis a range of projects based on the needs identified by the chemical round table have been chosen including amide synthesis, stereo- and regio-specific hydroxylation of complex molecules as well as other redox reactions. Again process engineering and supercritical solvents will be developed as intensification methods. In the third part the development of the emerging field of synthetic biology will be addressed with the development of enzymatic chemical cascade pathways in fermentation strains with freedom to operate to produce targets of interest.
Finally the outcomes of the efforts described will be incorporated into education and training efforts to produce the next generation of process chemists with a good understanding of green and sustainable metrics.

Field of science

  • /social sciences/economics and business/economics/sustainable economy
  • /engineering and technology/industrial biotechnology/bioprocessing technologies/biocatalysis
  • /natural sciences/biological sciences/synthetic biology

Call for proposal

IMI-JU-04-2011
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
Address
Great West Road 980
TW89GS Brentford
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Murray Brown (Dr)
Administrative Contact
Karen Philpott (Dr)

Participants (18)

THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 1 577 900
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms)
UNIVERSITY OF YORK
United Kingdom
EU contribution
€ 1 501 571
Address
Heslington
YO10 5DD York North Yorkshire
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chris Barber (Mr)
CatScI Ltd
United Kingdom
EU contribution
€ 172 871
Address
Capital Business Park
CF3 2PX Wentloog, Cardiff
Administrative Contact
Ross Burn (Dr)
ACIB GMBH
Austria
EU contribution
€ 1 340 581
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
Administrative Contact
Mandana Gruber (Dr.)
STICHTING VU
Netherlands
EU contribution
€ 504 773
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dirkje Schinkelshoek (Drs.)
UNIVERSITY OF DURHAM
United Kingdom
EU contribution
€ 152 505
Address
Stockton Road The Palatine Centre
DH1 3LE Durham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wendy Harle (Ms)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 565 403
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Mrs.)
UNIVERSITAET STUTTGART
Germany
EU contribution
€ 1 210 524
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernhard Hauer (Prof. Dr.)
LEIBNIZ - INSTITUT FUR KATALYSE EV AN DER UNIVERSITAT ROSTOCK
Germany
EU contribution
€ 733 400
Address
Albert-einstein-strasse 29A
18059 Rostock
Activity type
Research Organisations
Administrative Contact
Stefan Legler (Mr)
charnwood technical consulting ltd
United Kingdom
EU contribution
€ 232 578
Address
Northgate Close
LE12 8AT Quorn
Administrative Contact
Andrew Stephen Wells (Professor)
Reaxa Limited
United Kingdom
EU contribution
€ 150 100
Address
Leeds University
LS2 9JT Leeds
Administrative Contact
Tanmay Godiawala (Ms)
EVOLVA AG
Switzerland
EU contribution
€ 432 490
Address
Duggingerstrasse 23
4153 Reinach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Alessandro Del Fabro (Mr.)
UNIVERSITY OF LEEDS
United Kingdom
EU contribution
€ 1 254 942
Address
Woodhouse Lane
LS2 9JT Leeds
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Hamilton (Mr)
Sanofi Chimie
France
Address
Rue Du Président S. Allende
94250 Gentilly
Administrative Contact
Bénédicte Boursin (Manager)
ORION OYJ
Finland
Address
Orionintie 1
02200 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ville Hassinen (MSc economics)
Bayer Pharma AG
Germany
Address
Muellerstrasse 178
13353 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Freitag (Ms)
JANSSEN PHARMACEUTICA NV
Belgium
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wim Aelterman (Director Process R&D)
PFIZER LIMITED
United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
David Reynolds (Dr)