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Aetionomy – Organising Mechanistic Knowledge about Neurodegenerative Diseases for the Improvement of Drug Development and Therapy

Objective

IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and (II) the focused application of this pipeline to derive clinically significant mechanistic taxonomies of neurodegenerative diseases. These taxonomies will represent multi-scale structural and functional understanding of the causal mechanisms of and possible treatments in PD and AD. In particular, knowledge integration about neural substrates and their functional correlates will be generated through a pipeline that co-ordinates:

I. the manual knowledge acquisition of mechanistic neurological knowledge from clinical experts,

II. the semi-automated calculation of functional indices derived from clinical examination datasets, neuroradiological images and clinical and experimental investigation results,

III. the large-scale acquisition of further evidence about functional relationships between knowledge created in i & ii by mining electronic health records and the literature,

IV. the automated detection of significant correlations inferred from knowledge derived from steps i to iii above.

To that end, AETIONOMY has assembled a seasoned consortium of expert clinicians and scientists to build upon (A) previous work within the consortium, which comprises unpublished and published work (ontologies such as ADO, the Alzheimer´s Disease Ontology, in press in “Alzheimer´s & Dementia”; disease models such as the comprehensive CellDesigner model for PD build by partner LCSB) and (B) considerable public domain resources generated by large international communities (e.g. the Neuroscience Information Framework), and (C) results from ongoing IMI projects (e.g. DDMoRe, OpenPHACTS, eTRIKS, EMIF), providing a unique combination of tools and expertise to discover the core criteria that make for a good drug target and, in so doing, classify patients according to these criteria.

Field of science

  • /humanities/philosophy, ethics and religion/philosophy/metaphysics/ontology
  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /medical and health sciences/basic medicine/neurology/alzheimer

Call for proposal

IMI-JU-08-2012
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

UCB BIOPHARMA SRL
Address
Allee De La Recherche 60
1070 Bruxelles
Belgium
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Phil Scordis (Dr)
Administrative Contact
Katharina Klapper (Mrs)

Participants (17)

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 1 697 074
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
Administrative Contact
Tobias Rechmann (Mr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 314 835
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sander Woerdeman (NA)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 1 172 160
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker (Ms.)
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
EU contribution
€ 1 757 309
Address
Boulevard De L'hopital 47
75013 Paris
Activity type
Research Organisations
Administrative Contact
Iwona Jablonska (European & International Project Manager)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 284 220
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez Samper (Ms.)
GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Germany
EU contribution
€ 309 156
Address
Welfengarten 1
30167 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nikolaus Forgó (Prof. Dr.)
University College London

Participation ended

United Kingdom
EU contribution
€ 254 543
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Malgorzata Kielbasa (Ms)
SC NEURORAD SRL

Participation ended

Romania
EU contribution
€ 74 960
Address
Nicolae Iliesu
300730 Timisoara
Administrative Contact
Lucian Florea (Dr.)
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
Hungary
EU contribution
€ 359 103
Address
Derkovits Fasor 7-11
6726 Szeged
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tamás Letoha (Dr.)
UNIVERSITE DU LUXEMBOURG
Luxembourg
EU contribution
€ 325 355
Address
2 Avenue De L'universite
4365 Esch-sur-alzette
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alfred Funk (Mr)
ALZHEIMER EUROPE
Luxembourg
EU contribution
€ 99 000
Address
Rue Dicks 14
1417 Luxembourg
Activity type
Other
Administrative Contact
Jean Georges (Mr)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 845 950
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Caroline Hamilton (Ms)
NOVARTIS PHARMA AG
Switzerland
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Barbara Stolz (Dr.)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laurence Mazuranok (Ms)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Göggel (Dr.)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 264 357
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jonathan BARTOLI (European projects ingeneer manager)
FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER
Spain
EU contribution
€ 235 212
Address
Calle Wellington 30
08005 Barcelona
Activity type
Research Organisations
Administrative Contact
Karine Fauria (PhD)