Objective IMI’s Call 8 is geared to develop knowledge frameworks for ‘druggable mechanisms’ for two domains of pathophysiology. In response to this call, we propose (I) the development of a generic AETIONOMY pipeline to capture and infer over mechanistic knowledge of pathophysiology, and (II) the focused application of this pipeline to derive clinically significant mechanistic taxonomies of neurodegenerative diseases. These taxonomies will represent multi-scale structural and functional understanding of the causal mechanisms of and possible treatments in PD and AD. In particular, knowledge integration about neural substrates and their functional correlates will be generated through a pipeline that co-ordinates:I. the manual knowledge acquisition of mechanistic neurological knowledge from clinical experts,II. the semi-automated calculation of functional indices derived from clinical examination datasets, neuroradiological images and clinical and experimental investigation results,III. the large-scale acquisition of further evidence about functional relationships between knowledge created in i & ii by mining electronic health records and the literature,IV. the automated detection of significant correlations inferred from knowledge derived from steps i to iii above.To that end, AETIONOMY has assembled a seasoned consortium of expert clinicians and scientists to build upon (A) previous work within the consortium, which comprises unpublished and published work (ontologies such as ADO, the Alzheimer´s Disease Ontology, in press in “Alzheimer´s & Dementia”; disease models such as the comprehensive CellDesigner model for PD build by partner LCSB) and (B) considerable public domain resources generated by large international communities (e.g. the Neuroscience Information Framework), and (C) results from ongoing IMI projects (e.g. DDMoRe, OpenPHACTS, eTRIKS, EMIF), providing a unique combination of tools and expertise to discover the core criteria that make for a good drug target and, in so doing, classify patients according to these criteria. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencesknowledge engineeringontologymedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinephysiologypathophysiology Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-08-2012-04 - Developing An Aetiology-Based Taxonomy Of Human Disease - Approaches to Develop a New Classification for Neurodegenerative Disorders Call for proposal IMI-JU-08-2012 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator UCB BIOPHARMA Address Allee de la recherche 60 1070 Bruxelles / brussel Belgium See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator Phil Scordis (Dr) Administrative Contact Katharina Klapper (Mrs) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 1 743 513,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Tobias Rechmann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 314 835,00 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Sander Woerdeman (NA) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITATSKLINIKUM BONN Germany EU contribution € 1 172 160,00 Address Venusberg-campus 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Becker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE France EU contribution € 1 757 309,00 Address Boulevard de l'hopital 47 75013 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Iwona Jablonska (European & International Project Manager) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 340 710,00 Address Calle rossello 149 puerta bjs 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martinez Samper (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER Germany EU contribution € 276 855,00 Address Welfengarten 1 30167 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Nikolaus Forgó (Prof. Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY COLLEGE LONDON Participation ended United Kingdom EU contribution € 184 011,00 Address Gower street WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Malgorzata Kielbasa (Ms) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SC NEURORAD SRL Participation ended Romania EU contribution € 70 238,00 Address Nicolae iliesu 300730 Timisoara See on map Administrative Contact Lucian Florea (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT Hungary EU contribution € 359 103,00 Address Derkovits fasor 7-11 6726 Szeged See on map Region Alföld és Észak Dél-Alföld Csongrád Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Tamás Letoha (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITE DU LUXEMBOURG Luxembourg EU contribution € 325 355,00 Address 2 avenue de l'universite 4365 Esch-sur-alzette See on map Region Luxembourg Luxembourg Luxembourg Activity type Higher or Secondary Education Establishments Administrative Contact Alfred Funk (Mr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ALZHEIMER EUROPE Luxembourg EU contribution € 99 000,00 Address Rue dicks 14 1417 Luxembourg See on map Region Luxembourg Luxembourg Luxembourg Activity type Research Organisations Administrative Contact Jean Georges (Mr) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KAROLINSKA INSTITUTET Sweden EU contribution € 876 010,00 Address Nobels vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Ms) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NOVARTIS PHARMA AG Switzerland EU contribution € 0,00 Address Lichtstrasse 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Barbara Stolz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France EU contribution € 0,00 Address Pierre brossolette 1 91380 Chilly mazarin See on map Region Ile-de-France Ile-de-France Essonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Laurence Mazuranok (Ms) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BOEHRINGER INGELHEIM INTERNATIONALGMBH Germany EU contribution € 0,00 Address Binger strasse 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rolf Göggel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITE D'AIX MARSEILLE France EU contribution € 264 357,00 Address Boulevard charles livon 58 le pharo 13284 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Jonathan BARTOLI (European projects ingeneer manager) Links Contact the organisation Opens in new window Other funding No data FUNDACIO BARCELONABETA BRAIN RESEARCH CENTER Spain EU contribution € 209 778,00 Address Calle wellington 30 08005 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Karine Fauria (PhD) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
