Objective Active pharmaceutical ingredients (APIs) can be released to the natural environment during the manufacturing process, following use by patients or when unused medicines are disposed of. As APIs are biologically active compounds concerns have been raised about the potential effects of APIs in the environment on human and environmental health. Over the past 15 years, a substantial amount of work has been done to determine the occurrence, fate, effects, and resulting risks of APIs in the environment and regulatory schemes have been developed requiring environmental risk assessments of all new APIs. However for most APIs currently in use, limited data are available on environmental risks and for new APIs, the testing regimes may not always be optimum. The aim of this project therefore is to develop frameworks that utilise information from toxicological studies, pharmacological mode of action and in silico models to support more intelligent environmental testing of pharmaceuticals in development and to prioritise legacy pharmaceuticals for full environmental risk assessment and/or environmental (bio) monitoring. The aim will be delivered through a number of specific objectives: 1) to review existing approaches for prioritisation and mode of action based intelligent testing of APIs and develop improved frameworks; 2) to establish a high quality database on the properties, environmental fate characteristics and ecotoxicity of APIs; 3) to develop methods for estimating external and internal exposure to APIs for different scenarios; 4) to develop methods and models for predicting ecotoxicological responses to APIs; 5) to validate the developed models, concepts and frameworks using targeted experiments; and 6) to develop a software system to support intelligent testing and prioritisation of APIs in the environment. These objectives will be delivered by a world leading consortium comprising experts in data management and computational modelling, pharmacology, ecotoxicology, environmental chemistry, predictive (eco)toxicology, prioritisation and intelligent testing methodologies and environmental risk assessment. Fields of science medical and health scienceshealth sciencespublic healthmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencescomputer and information sciencessoftwaresoftware applicationssystem software Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-11-2013-08 - Ecoriskprediction (ERP) Call for proposal IMI-JU-11-2013 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator BAYER AKTIENGESELLSCHAFT EU contribution No data Address KAISER-WILHELM-ALLEE 1 51373 Leverkusen Germany See on map Region Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (25) Sort alphabetically Sort by EU Contribution Expand all Collapse all FUNDACIO INSTITUT HOSPITAL DEL MAR D INVESTIGACIONS MEDIQUES Spain EU contribution € 150 157,00 Address Doctor Aiguader 88 08003 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF YORK United Kingdom EU contribution € 394 255,00 Address HESLINGTON YO10 5DD York North Yorkshire See on map Region Yorkshire and the Humber North Yorkshire York Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ Germany EU contribution € 262 862,00 Address PERMOSERSTRASSE 15 04318 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECT OEKOTOXIKOLOGIE GMBH Germany EU contribution € 332 459,00 Address BOTTGERSTRASSE 2-14 65439 Florsheim See on map Region Hessen Darmstadt Main-Taunus-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 360 400,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UMWELTBUNDESAMT Germany EU contribution € 186 677,00 Address Woerlitzer Platz 1 06844 Dessau-Rosslau See on map Region Sachsen-Anhalt Sachsen-Anhalt Dessau-Roßlau, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF EXETER United Kingdom EU contribution € 258 566,00 Address THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Spain EU contribution € 224 866,00 Address CALLE VELAZQUEZ 94 PLANTA 1 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD POMPEU FABRA Spain EU contribution € 125 583,00 Address PLACA DE LA MERCE, 10-12 08002 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LHASA LIMITED United Kingdom EU contribution € 288 640,00 Address GRANARY WHARF HOUSE, 2 CANAL WHARF LS11 5PS Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MOLECULAR NETWORKS GMBH COMPUTERCHEMIE Germany EU contribution € 258 475,00 Address NEUMEYERSTR 28-34 90411 Nurnberg See on map Region Bayern Mittelfranken Nürnberg, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LIVERPOOL JOHN MOORES UNIVERSITY United Kingdom EU contribution € 157 060,00 Address RODNEY STREET 2 EGERTON COURT L3 5UX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BRISTOL-MYERS SQUIBB COMPANY CORP United States EU contribution No data Address PARK AVENUE 345 10154 New York See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. United Kingdom EU contribution No data Address Great West Road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JANSSEN PHARMACEUTICA NV Belgium EU contribution No data Address TURNHOUTSEWEG 30 2340 Beerse See on map Region Vlaams Gewest Prov. Antwerpen Arr. Turnhout Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ELI LILLY AND COMPANY LTD United Kingdom EU contribution No data Address LILLY HOUSE BASINGVIEW RG21 4FA Basingstoke See on map Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MERCK SHARP & DOHME CORP United States EU contribution No data Address ONE MERCK DRIVE 08889 Whitehouse Station Nj See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data F. HOFFMANN-LA ROCHE AG Switzerland EU contribution No data Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASTRAZENECA AB Sweden EU contribution No data Address Vastra Maelarhamnen 151 85 Sodertaelje See on map Region Östra Sverige Stockholm Stockholms län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France EU contribution No data Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PFIZER LIMITED United Kingdom EU contribution No data Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVARTIS PHARMA AG Switzerland EU contribution No data Address LICHTSTRASSE 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BOEHRINGER INGELHEIM INTERNATIONALGMBH Germany EU contribution No data Address BINGER STRASSE 55218 Ingelheim See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEVA PHARMACEUTICALS EUROPE B.V. Participation ended Netherlands EU contribution No data Address PIET HEINKADE 107 1019 GM AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEVA PHARMACEUTICALS EUROPE B.V. Netherlands EU contribution No data Address PIET HEINKADE 107 1019 GM AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data