Ebola Virus: Modern Approaches for developing bedside Rapid Diagnostics – Sofia ref.: 115843

Project Information

EbolaMoDRAD

Grant agreement ID: 115843

DOI 10.3030/115843

Project closed

EC signature date 21 January 2015

Start date 1 February 2015

End date 31 January 2018

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost € 4 300 935,00

EU contribution € 4 300 935,00

Coordinated by

FOLKHALSOMYNDIGHETEN
Sweden

Deliverables

Documents, reports (6)

Design, develop and validate isothermal detection assays based on RPA, LAMP and hRCA technology

Migration

Report on course/workshop on outbreak management

Migration

Validation and field trials report

Migration

Report on course/workshop in field diagnostic

Migration

Report on course/workshop on clinical aspects of emerging disease

Migration

Validate QRT-PCR assays

Migration

Demonstrators, pilots, prototypes (2)

Field usable filer tipp based RNA extraction

Migration

Design, develop and validate Ebola detection in an automated and closed system

Migration

Publications

Peer reviewed articles (13)

Rapid Bedside Inactivation of Ebola Virus for Safe Nucleic Acid Tests

Author(s): Maiken Worsøe Rosenstierne, Helen Karlberg, Karoline Bragstad, Gunnel Lindegren, Malin Lundahl Stoltz, Cristiano Salata, Anne-Marte Bakken Kran, Susanne Gjeruldsen Dudman, Ali Mirazimi, Anders Fomsgaard
Published in: Journal of Clinical Microbiology, Issue 54/10, 2016, Page(s) 2521-2529, ISSN 0095-1137
Publisher: American Society for Microbiology
DOI: 10.1128/JCM.00346-16

The Pasteur Laboratory associated with the Ebola Treatment Center of Macenta (Guinea)

Author(s): Stéphanie Reynard, Alexandra Fizet, Caroline Picard, Sylvain Baize
Published in: Clinical Microbiology and Infectious Diseases, Issue 1/4, 2016, ISSN 2398-8096
Publisher: OAT
DOI: 10.15761/CMID.1000S1002

Yoctomole electrochemical genosensing of Ebola virus cDNA by rolling circle and circle to circle amplification

Author(s): S. Carinelli, M. Kühnemund, M. Nilsson, M.I. Pividori
Published in: Biosensors and Bioelectronics, Issue 93, 2017, Page(s) 65-71, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2016.09.099

A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer

Author(s): Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt
Published in: PLOS ONE, Issue 13/2, 2018, Page(s) e0191872, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0191872

Synthesis of Oligo-(alkyne-triplet)peptide Constructs

Author(s): Nicolai Stuhr-Hansen, Christian Risinger, Ebbe Engholm, Ola Blixt
Published in: Organic Letters, Issue 19/24, 2017, Page(s) 6522-6525, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.7b03231

EBOLA Ag K -SeT rapid test: field evaluation in Sierra Leone

Author(s): F. Colavita, M. Biava, P. Mertens, Q. Gilleman, C. Borlon, M. Delli Guanti, A. Petrocelli, G. Cataldi, A.T. Kamara, S.A. Kamara, K. Konneh, D. Vincenti, C. Castilletti, S. Abdurahman, A. Mirazimi, M.R. Capobianchi, G. Ippolito, R. Miccio, A. Di Caro
Published in: Clinical Microbiology and Infection, Issue 24/6, 2018, Page(s) 653-657, ISSN 1198-743X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.cmi.2017.10.019

Ebolavirus protein VP24 interferes with innate immune responses by inhibiting interferon-λ1 gene expression

Author(s): Felix He, Krister Melén, Sari Maljanen, Rickard Lundberg, Miao Jiang, Pamela Österlund, Laura Kakkola, Ilkka Julkunen
Published in: Virology, Issue 509, 2017, Page(s) 23-34, ISSN 0042-6822
Publisher: Academic Press
DOI: 10.1016/j.virol.2017.06.002

Fidelity of RNA templated end-joining by chlorella virus DNA ligase and a novel iLock assay with improved direct RNA detection accuracy

Author(s): Tomasz Krzywkowski, Mats Nilsson
Published in: Nucleic Acids Research, Issue 45/18, 2017, Page(s) e161-e161, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkx708

Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Author(s): Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Published in: Journal of Virology, Issue 91/10, 2017, Page(s) e02076-16, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/JVI.02076-16

Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations

Author(s): Géraldine Piorkowski, Frédéric Jacquot, Gilles Quérat, Caroline Carbonnelle, Delphine Pannetier, France Mentré, Hervé Raoul, Xavier de Lamballerie
Published in: Antiviral Research, Issue 140, 2017, Page(s) 95-105, ISSN 0166-3542
Publisher: Elsevier BV
DOI: 10.1016/j.antiviral.2017.01.017

Evaluation of a rapid and sensitive RT-qPCR assay for the detection of Ebola Virus

Author(s): M. Biava, F. Colavita, A. Marzorati, D. Russo, D. Pirola, A. Cocci, A. Petrocelli, M. Delli Guanti, G. Cataldi, T.A. Kamara, A.S. Kamara, K. Konneh, A. Cannas, S. Coen, S. Quartu, S. Meschi, M.B. Valli, A. Mazzarelli, C. Venditti, G. Grassi, G. Rozera, C. Castilletti, A. Mirazimi, M.R. Capobianchi, G. Ippolito, R. Miccio, A. Di Caro
Published in: Journal of Virological Methods, Issue 252, 2018, Page(s) 70-74, ISSN 0166-0934
Publisher: Elsevier BV
DOI: 10.1016/j.jviromet.2017.11.009

Sensitive and inexpensive digital DNA analysis by microfluidic enrichment of rolling circle amplified single-molecules

Author(s): Malte Kühnemund, Iván Hernández-Neuta, Mohd Istiaq Sharif, Matteo Cornaglia, Martin A.M. Gijs, Mats Nilsson
Published in: Nucleic Acids Research, Issue 45(8), 2017, Page(s) gkw1324, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkw1324

Measles Cases during Ebola Outbreak, West Africa, 2013–2106

Author(s): Francesca Colavita, Mirella Biava, Concetta Castilletti, Serena Quartu, Francesco Vairo, Claudia Caglioti, Chiara Agrati, Eleonora Lalle, Licia Bordi, Simone Lanini, Michela Delli Guanti, Rossella Miccio, Giuseppe Ippolito, Maria R. Capobianchi, Antonino Di Caro
Published in: Emerging Infectious Diseases, Issue 23/6, 2017, Page(s) 1035-1037, ISSN 1080-6040
Publisher: US National Center for Infectious Diseases
DOI: 10.3201/eid2306.161682

Non-peer reviewed articles (3)

INMI/Emergency NGO Italian Laboratory Established In Sierra Leone during Ebola Virus Disease Outbreak in West Africa

Author(s): Francesca Colavita, Carolina Venditti, Antonella Vulcano, Concetta Castilletti, Paola Zaccaro, Antonio Mazzarelli, Serena Quartu, Sabrina Coen, Angela Cannas, Roberta Chiappini, Claudia Minosse, Silvia Meschi, Mirella Biava, Stefano Menzo, Maria Beatrice Valli, Germana Grassi, Daniele Lapa, Francesco Vairo, Gina Portella, Rossella Miccio, Enrico Sponziello, Luca Rolla, Michela Delli Guanti, Milos
Published in: Clinical Microbiology and Infectious Diseases, Issue 1/4, 2016, ISSN 2398-8096
Publisher: INMI
DOI: 10.15761/CMID.1000S1001

Linear Multiepitope (Glyco)peptides for Type-Specific Serology of Herpes Simplex Virus (HSV) Infections

Author(s): Christian Risinger, Kasper K. Sørensen, Knud J. Jensen, Sigvard Olofsson, Tomas Bergström, Ola Blixt
Published in: ACS Infectious Diseases, Issue 3/5, 2017, Page(s) 360-367, ISSN 2373-8227
Publisher: ACS Publications
DOI: 10.1021/acsinfecdis.7b00001

Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques

Author(s): Jérémie Guedj, Géraldine Piorkowski, Frédéric Jacquot, Vincent Madelain, Thi Huyen Tram Nguyen, Anne Rodallec, Stephan Gunther, Caroline Carbonnelle, France Mentré, Hervé Raoul, Xavier de Lamballerie
Published in: PLOS Medicine, Issue 15/3, 2018, Page(s) e1002535, ISSN 1549-1676
Publisher: PMed
DOI: 10.1371/journal.pmed.1002535