Vaccine lot to Vaccine lot comparison by consistency testing.

Deliverables

Project meetings and conferences.

Migration

Establishment of SEAC.

Migration

Scientific and administrative-financial reporting.

Migration

Preparation of communication material including launch of project webpage.

Migration

Publications

Characterisation of diphtheria monoclonal antibodies as a first step towards the development of an in vitro vaccine potency immunoassay

Author(s): Rebecca Riches-Duit, Laura Hassall, Amy Kogelman, Janny Westdijk, Alexandre Dobly, Antoine Francotte, Paul Stickings
Published in: Biologicals, Issue 69, 2021, Page(s) 38-48, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2020.12.002

Characterisation of tetanus monoclonal antibodies as a first step towards the development of an in vitro vaccine potency immunoassay

Author(s): Rebecca Riches-Duit, Laura Hassall, Amy Kogelman, Janny Westdijk, Shalini Rajagopal, Bazbek Davletov, Ciara Doran, Alexandre Dobly, Antoine Francotte, Paul Stickings
Published in: Biologicals, Issue 71, 2021, Page(s) 31-41, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2021.04.002

Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine

Author(s): Robin H.G.A. van den Biggelaar, Larissa van der Maas, Hugo D. Meiring, Jeroen L.A. Pennings, Willem van Eden, Victor P.M.G. Rutten, and Christine A. Jansen
Published in: Scientific Reports, 2021, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-021-89810-3

Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation

Author(s): Rob J. Vandebriel, Coen A.L. Stalpers, Jolanda P. Vermeulen, Mariska Remkes, Marit Schmelter, Femke Broere, and Marcel H.N. Hoefnagel
Published in: Vaccine, Issue Vol. 40, Iss. 38, 9 September 2022, 2022, Page(s) 5601-5607, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2022.08.022

A cell-based in vitro assay for testing of immunological integrity of Tetanus toxoid vaccine antigen

Author(s): Olga Ticha, Dido Klemm, Lukas Moos & Isabelle Bekeredjian-Ding
Published in: npj Vaccines, 2021, ISSN 2059-0105
Publisher: Nature Publishing Group
DOI: 10.1038/s41541-021-00344-1

Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis virus

Author(s): Marilena P. Etna, Aurora Signorazzi, Daniela Ricci, Martina Severa, Fabiana Rizzo, Elena Giacomini, Andrea Gaggioli, Isabelle Bekeredjian-Ding, Anke Huckriede, Eliana M. Coccia
Published in: PLOS Pathogens, Issue 17/4, 2021, Page(s) e1009505, ISSN 1553-7374
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1009505

Activation of canine, mouse and human TLR2 and TLR4 by inactivated Leptospira vaccine strains

Author(s): Andreja Novak, Elder Pupo, Esther Van't Veld, Victor P. Rutten, Femke Broere, and Arjen Sloots
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.823058

Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid

Author(s): Thomas J. M. Michiels, Madelief A. van Veen, Hugo D. Meiring, Wim Jiskoot, Gideon F. A. Kersten, Bernard Metz
Published in: Journal of the American Society for Mass Spectrometry, Issue 32/6, 2021, Page(s) 1490-1497, ISSN 1044-0305
Publisher: Elsevier BV
DOI: 10.1021/jasms.1c00070

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Author(s): Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz
Published in: Vaccines, Issue 8/4, 2020, Page(s) 712, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040712

In Vitro Characterization of the Innate Immune Pathways Engaged by Live and Inactivated Tick-Borne Encephalitis Virus

Author(s): Aurora Signorazzi, Jeroen L. A. Pennings, Marilena P. Etna, Malou Noya, Eliana M. Coccia, Anke Huckriede
Published in: Vaccines, Issue 9/6, 2021, Page(s) 664, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060664

Optimization of the monocyte-activation-test for evaluating pyrogenicity of tick-borne encephalitis virus vaccine

Author(s): Marilena Etna
Published in: ALTEX, Issue 37, 2020, ISSN 1868-596X
Publisher: Springer Spektrum
DOI: 10.14573/altex.2002252

Effects of long-term cryopreservation of PBMC on recovery of B cell subpopulations

Author(s): Olga Ticha, Lukas Moos, Isabelle Bekeredjian-Ding
Published in: Journal of Immunological Methods, Issue 495, 2021, Page(s) 113081, ISSN 0022-1759
Publisher: Elsevier BV
DOI: 10.1016/j.jim.2021.113081

Recommendations of the VAC2VAC workshop on the design of multi-centre validation studies

Author(s): Marlies Halder, Hilde Depraetere, Frédérique Delannois, Arnoud Akkermans, Marie-Emmanuelle Behr-Gross, Martijn Bruysters, Jean-François Dierick, Carmen Jungbäck, Imke Kross, Bernard Metz, Jeroen Pennings, Peter Rigsby, Patrice Riou, Elisabeth Balks, Alexandre Dobly, Odile Leroy, Catrina Stirling
Published in: Biologicals, Issue 52, 2018, Page(s) 78-82, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2018.01.003

Evaluation of a capture antigen ELISA for the characterisation of tetanus vaccines for veterinary use

Author(s): Rebecca Riches-Duit, Laura Hassall, Peter Rigsby, Paul Stickings
Published in: Biologicals, Issue 61, 2019, Page(s) 8-14, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2019.08.003

A next-generation sequencing based method for determining genetic stability in Clostridium tetani vaccine strains

Author(s): Jeroen L.A. Pennings, Eric Abachin, Sylvie Uhlrich, Raphaël Esson, Laurent Mallet, Rob J. Vandebriel
Published in: Biologicals, Issue 64, 2020, Page(s) 10-14, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2020.02.001

In vitro Chicken Bone Marrow-Derived Dendritic Cells Comprise Subsets at Different States of Maturation

Author(s): Robin H. G. A. van den Biggelaar, Ger J. A. Arkesteijn, Victor P. M. G. Rutten, Willem van Eden, Christine A. Jansen
Published in: Frontiers in Immunology, Issue 11, 2020, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2020.00141

In vitro assessment of tick-borne encephalitis vaccine: Suitable human cell platforms and potential biomarkers

Author(s): Aurora Signorazzi, Marilena P. Etna, Eliana M. Coccia, and Anke Huckriede
Published in: ALTEX, Issue 38, 2021, ISSN 1868-596X
Publisher: Springer Spektrum
DOI: 10.14573/altex.2010081

Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines

Author(s): Coen A.L. Stalpers, Irene A. Retmana, Jeroen L.A. Pennings, Rob J. Vandebriel, Coenraad F.M. Hendriksen, Arnoud M. Akkermans, Marcel H.N. Hoefnagel
Published in: Vaccine, Issue 39/18, 2021, Page(s) 2506-2516, ISSN 0264-410X
Publisher: Elsevier BV
DOI: 10.1016/j.vaccine.2021.03.078

Nitric Oxide Production and Fc Receptor-Mediated Phagocytosis as Functional Readouts of Macrophage Activity upon Stimulation with Inactivated Poultry Vaccines In Vitro

Author(s): Robin van den Biggelaar, Willem van Eden, Victor Rutten, Christine Jansen
Published in: Vaccines, Issue 8/2, 2020, Page(s) 332, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020332

Macrophage Activation Assays to Evaluate the Immunostimulatory Capacity of Avibacterium paragallinarum in A Multivalent Poultry Vaccine

Author(s): Robin H. G. A. van den Biggelaar, Willem van Eden, Victor P. M. G. Rutten, Christine A. Jansen
Published in: Vaccines, Issue 8/4, 2020, Page(s) 671, ISSN 2076-393X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040671

Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions

Author(s): Jeroen L.A. Pennings, Eric Abachin, Raphael Esson, Hennie Hoedemaekers, Antoine Francotte, Jean-Baptiste Claude, Celine Vanhee, Sylvie Uhlrich, and Rob J. Vandebriel
Published in: Toxins, 2022, ISSN 2072-6651
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14010031

Mass spectrometry-based degradomics analysis of toxoid vaccines

Author(s): Thomas Michiels
Published in: 2021
Publisher: Leiden University

Animal testing for vaccines. Implementing replacement, reduction and refinement: challenges and priorities.

Author(s): Akkermans A, Chapsal JM, Coccia EM, Depraetere H, Dierick JF, Duangkhae P, Goel S, Halder M, Hendriksen C, Levis R, Pinyosukhee K, Pullirsch D, Sanyal G, Shi L, Sitrin R, Smith D, Stickings P, Terao E, Uhlrich S, Viviani L, Webster J.
Published in: Biologicals, Issue 68, 2020, ISSN 1045-1056
Publisher: Academic Press
DOI: 10.1016/j.biologicals.2020.07.010

Deliverables

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