Vaccine lot to Vaccine lot comparison by consistency testing.

Risultati finali

Project meetings and conferences.

Migration

Establishment of SEAC.

Migration

Scientific and administrative-financial reporting.

Migration

Preparation of communication material including launch of project webpage.

Migration

Pubblicazioni

Characterisation of diphtheria monoclonal antibodies as a first step towards the development of an in vitro vaccine potency immunoassay

Autori: Rebecca Riches-Duit, Laura Hassall, Amy Kogelman, Janny Westdijk, Alexandre Dobly, Antoine Francotte, Paul Stickings
Pubblicato in: Biologicals, Numero 69, 2021, Pagina/e 38-48, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2020.12.002

Characterisation of tetanus monoclonal antibodies as a first step towards the development of an in vitro vaccine potency immunoassay

Autori: Rebecca Riches-Duit, Laura Hassall, Amy Kogelman, Janny Westdijk, Shalini Rajagopal, Bazbek Davletov, Ciara Doran, Alexandre Dobly, Antoine Francotte, Paul Stickings
Pubblicato in: Biologicals, Numero 71, 2021, Pagina/e 31-41, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2021.04.002

Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine

Autori: Robin H.G.A. van den Biggelaar, Larissa van der Maas, Hugo D. Meiring, Jeroen L.A. Pennings, Willem van Eden, Victor P.M.G. Rutten, and Christine A. Jansen
Pubblicato in: Scientific Reports, 2021, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-021-89810-3

Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation

Autori: Rob J. Vandebriel, Coen A.L. Stalpers, Jolanda P. Vermeulen, Mariska Remkes, Marit Schmelter, Femke Broere, and Marcel H.N. Hoefnagel
Pubblicato in: Vaccine, Numero Vol. 40, Iss. 38, 9 September 2022, 2022, Pagina/e 5601-5607, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2022.08.022

A cell-based in vitro assay for testing of immunological integrity of Tetanus toxoid vaccine antigen

Autori: Olga Ticha, Dido Klemm, Lukas Moos & Isabelle Bekeredjian-Ding
Pubblicato in: npj Vaccines, 2021, ISSN 2059-0105
Editore: Nature Publishing Group
DOI: 10.1038/s41541-021-00344-1

Human plasmacytoid dendritic cells at the crossroad of type I interferon-regulated B cell differentiation and antiviral response to tick-borne encephalitis virus

Autori: Marilena P. Etna, Aurora Signorazzi, Daniela Ricci, Martina Severa, Fabiana Rizzo, Elena Giacomini, Andrea Gaggioli, Isabelle Bekeredjian-Ding, Anke Huckriede, Eliana M. Coccia
Pubblicato in: PLOS Pathogens, Numero 17/4, 2021, Pagina/e e1009505, ISSN 1553-7374
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1009505

Activation of canine, mouse and human TLR2 and TLR4 by inactivated Leptospira vaccine strains

Autori: Andreja Novak, Elder Pupo, Esther Van't Veld, Victor P. Rutten, Femke Broere, and Arjen Sloots
Pubblicato in: Frontiers in Immunology, 2022, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2022.823058

Common Reference-Based Tandem Mass Tag Multiplexing for the Relative Quantification of Peptides: Design and Application to Degradome Analysis of Diphtheria Toxoid

Autori: Thomas J. M. Michiels, Madelief A. van Veen, Hugo D. Meiring, Wim Jiskoot, Gideon F. A. Kersten, Bernard Metz
Pubblicato in: Journal of the American Society for Mass Spectrometry, Numero 32/6, 2021, Pagina/e 1490-1497, ISSN 1044-0305
Editore: Elsevier BV
DOI: 10.1021/jasms.1c00070

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Autori: Thomas J. M. Michiels, Wichard Tilstra, Martin R. J. Hamzink, Justin W. de Ridder, Maarten Danial, Hugo D. Meiring, Gideon F. A. Kersten, Wim Jiskoot, Bernard Metz
Pubblicato in: Vaccines, Numero 8/4, 2020, Pagina/e 712, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040712

In Vitro Characterization of the Innate Immune Pathways Engaged by Live and Inactivated Tick-Borne Encephalitis Virus

Autori: Aurora Signorazzi, Jeroen L. A. Pennings, Marilena P. Etna, Malou Noya, Eliana M. Coccia, Anke Huckriede
Pubblicato in: Vaccines, Numero 9/6, 2021, Pagina/e 664, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines9060664

Optimization of the monocyte-activation-test for evaluating pyrogenicity of tick-borne encephalitis virus vaccine

Autori: Marilena Etna
Pubblicato in: ALTEX, Numero 37, 2020, ISSN 1868-596X
Editore: Springer Spektrum
DOI: 10.14573/altex.2002252

Effects of long-term cryopreservation of PBMC on recovery of B cell subpopulations

Autori: Olga Ticha, Lukas Moos, Isabelle Bekeredjian-Ding
Pubblicato in: Journal of Immunological Methods, Numero 495, 2021, Pagina/e 113081, ISSN 0022-1759
Editore: Elsevier BV
DOI: 10.1016/j.jim.2021.113081

Recommendations of the VAC2VAC workshop on the design of multi-centre validation studies

Autori: Marlies Halder, Hilde Depraetere, Frédérique Delannois, Arnoud Akkermans, Marie-Emmanuelle Behr-Gross, Martijn Bruysters, Jean-François Dierick, Carmen Jungbäck, Imke Kross, Bernard Metz, Jeroen Pennings, Peter Rigsby, Patrice Riou, Elisabeth Balks, Alexandre Dobly, Odile Leroy, Catrina Stirling
Pubblicato in: Biologicals, Numero 52, 2018, Pagina/e 78-82, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2018.01.003

Evaluation of a capture antigen ELISA for the characterisation of tetanus vaccines for veterinary use

Autori: Rebecca Riches-Duit, Laura Hassall, Peter Rigsby, Paul Stickings
Pubblicato in: Biologicals, Numero 61, 2019, Pagina/e 8-14, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2019.08.003

A next-generation sequencing based method for determining genetic stability in Clostridium tetani vaccine strains

Autori: Jeroen L.A. Pennings, Eric Abachin, Sylvie Uhlrich, Raphaël Esson, Laurent Mallet, Rob J. Vandebriel
Pubblicato in: Biologicals, Numero 64, 2020, Pagina/e 10-14, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2020.02.001

In vitro Chicken Bone Marrow-Derived Dendritic Cells Comprise Subsets at Different States of Maturation

Autori: Robin H. G. A. van den Biggelaar, Ger J. A. Arkesteijn, Victor P. M. G. Rutten, Willem van Eden, Christine A. Jansen
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/fimmu.2020.00141

In vitro assessment of tick-borne encephalitis vaccine: Suitable human cell platforms and potential biomarkers

Autori: Aurora Signorazzi, Marilena P. Etna, Eliana M. Coccia, and Anke Huckriede
Pubblicato in: ALTEX, Numero 38, 2021, ISSN 1868-596X
Editore: Springer Spektrum
DOI: 10.14573/altex.2010081

Variability of in vivo potency tests of Diphtheria, Tetanus and acellular Pertussis (DTaP) vaccines

Autori: Coen A.L. Stalpers, Irene A. Retmana, Jeroen L.A. Pennings, Rob J. Vandebriel, Coenraad F.M. Hendriksen, Arnoud M. Akkermans, Marcel H.N. Hoefnagel
Pubblicato in: Vaccine, Numero 39/18, 2021, Pagina/e 2506-2516, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/j.vaccine.2021.03.078

Nitric Oxide Production and Fc Receptor-Mediated Phagocytosis as Functional Readouts of Macrophage Activity upon Stimulation with Inactivated Poultry Vaccines In Vitro

Autori: Robin van den Biggelaar, Willem van Eden, Victor Rutten, Christine Jansen
Pubblicato in: Vaccines, Numero 8/2, 2020, Pagina/e 332, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8020332

Macrophage Activation Assays to Evaluate the Immunostimulatory Capacity of Avibacterium paragallinarum in A Multivalent Poultry Vaccine

Autori: Robin H. G. A. van den Biggelaar, Willem van Eden, Victor P. M. G. Rutten, Christine A. Jansen
Pubblicato in: Vaccines, Numero 8/4, 2020, Pagina/e 671, ISSN 2076-393X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines8040671

Regulation of Clostridium tetani Neurotoxin Expression by Culture Conditions

Autori: Jeroen L.A. Pennings, Eric Abachin, Raphael Esson, Hennie Hoedemaekers, Antoine Francotte, Jean-Baptiste Claude, Celine Vanhee, Sylvie Uhlrich, and Rob J. Vandebriel
Pubblicato in: Toxins, 2022, ISSN 2072-6651
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/toxins14010031

Mass spectrometry-based degradomics analysis of toxoid vaccines

Autori: Thomas Michiels
Pubblicato in: 2021
Editore: Leiden University

Animal testing for vaccines. Implementing replacement, reduction and refinement: challenges and priorities.

Autori: Akkermans A, Chapsal JM, Coccia EM, Depraetere H, Dierick JF, Duangkhae P, Goel S, Halder M, Hendriksen C, Levis R, Pinyosukhee K, Pullirsch D, Sanyal G, Shi L, Sitrin R, Smith D, Stickings P, Terao E, Uhlrich S, Viviani L, Webster J.
Pubblicato in: Biologicals, Numero 68, 2020, ISSN 1045-1056
Editore: Academic Press
DOI: 10.1016/j.biologicals.2020.07.010

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