Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in HematologY - Sofia ref.: 116026 | HARMONY | Projet | Résultats | H2020 | CORDIS

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Common minimum data sets

Migration

Identification of follow-up data for endpoint analysis

Migration

Definition of user access requirements

Migration

PHSFF contribution to the Access Evidence and Clinical Value Frameworks

Migration

Position/white papers

To address, e.g. policy makers, authorities, patient advocates, etc., to the policy/health economic implications of the outcomes of the research performed on the databases available in the project, in conjunction with WP6.

Alignment of data with clinically meaningful outcomes

Migration

Dissemination of results by publications

Migration

Communication strategy and plan

Migration

Newsletters

Migration

Point of contact/advisors

Migration

Searching for gender differences in diagnosis/outcome

Migration

Policy Health Stakeholder Feedback Forum (PHSFF) members identified and established

Migration

Development of the HM-specific Evidence Framework

Migration

Final Report Platform Monitoring Service

Migration

Ethics Committee, Monitoring and Management

Independent Ethics Advisory Board (EAB): nominating members, review and approval of the consortium feedback on the ethics screening report and implementation in DoA of their recommendations, if any; ethics consulting and periodic ethics reporting by the EAB.

Guidance document on optimal outcome measures in HMs (white paper)

Migration

Outcome measures relevant to additional HM diseases / other rare cancers

Migration

Social media

Development and management of a social media (Facebook, Twitter, etc.) presence to allow for interactive communication and also sharing with the health-interest public and patients.

Development of the HARMONY Added Value Framework (HAVF)

Dependent on deliverables D201 and D204 on the definition of Core Outcome Sets COS it will include a White Paper on currently available Value Frameworks VFs and the publication of the HARMONY Added Value Framework HAVF on M56 The scoping and development of a value framework in HM is a lengthy process 3 to 5 years from start to validation and the finalization of the HAVF may fall out of scope of HARMONYs funding period Should this be the case the deliverable will only comprise the white paper on currently available Value Frameworks

Updated and final version of D6.01 (Policy Health Stakeholder Feedback Forum)

Reports about the outcomes of PHSFF consultations and meetings

Guidance document on incidental findings

Migration

Handbook on ethical considerations of fundamental rights in the secondary use of medical data

Migration

International conferences

Throughout the project, various international conferences will be used to disseminate the results of the project and raise awareness among the general public.

Co-ordination with BD4BO and CSA

(Depending on progress of calls and projects): reports on co-ordination activities, joint actions and knowledge exchange between HARMONY and other IMI, BD4BO and CSA projects (M06/M36/M78).

Guidance on anonymization and pseudonymization

Migration

HARMONY platform component deployment

Migration

Definition of standard outcome sets and data quality assessment applicable to all HMs

Migration

"Reports on ""Health literacy"""

Migration

Guidance document on data protection and privacy rules

Migration

Updated and final version of D4.06 Rules for defined first question

HARMONY Research Projects dictate the rules required for effectively addressing a specific research question and the data collected. This deliverable will collect the rules of research projects approved after the submission of D4.06

Rules for defined first question within each HM

Migration

"""Qualification for novel methodologies"" stakeholders guide"

An explanatory document presenting the process and the steps toward submission of a topic QoNM process The first version will be reay for M31 July 2019 and a revised version done in M60 December 2021

Press releases

Regular press releases will raise awareness about the project, and will make particular use of the media contacts of various partners in the project to create awareness in the world of medical journalism.

Case management: Security and Governance FW

Migration

“Proof-of-Principle” study

Migration

Definition of all sets of outcomes for individual HMs

Migration

A review of EMA initiatives relevant to HARMONY database use and enhancing the visibility of HARMONY

This deliverable will present a brief report providing short summaries to the key initiatives identified: outline of initiative and relevance to HARMONY, status (complete / ongoing / outputs expected / consultation / workshops, etc.), contact point, and links to key documents and resources.

Website and repository

Migration

Training/dissemination events

These events are aimed at engaging, e.g. policy makers, authorities, patient advocates, etc., to discuss the policy/health economic implications of the outcomes of the research performed on the databases available in the project, in conjunction with WP6.

Publications

From Clonal Hematopoiesis to Therapy-Related Myeloid Neoplasms: The Silent Way of Cancer Progression

Auteurs: Carmelo Gurnari; Emiliano Fabiani; Emiliano Fabiani; Giulia Falconi; Serena Travaglini; Tiziana Ottone; Antonio Cristiano; Maria Teresa Voso
Publié dans: Biology, Vol 10, Iss 128, p 128 (2021), Numéro 1, 2021, Page(s) 1-14, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology10020128

Merging 1D and 3D genomic information: Challenges in modelling and validation

Auteurs: Merlotti, Alessandra; Rosa, Angelo; Remondini, Daniel
Publié dans: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Numéro 1, 2020, Page(s) Volume 1863, Numéro 6, ISSN 1874-9399
Éditeur: Elsevier BV
DOI: 10.1016/j.bbagrm.2019.194415

When Poisons Cure: The Case of Arsenic in Acute Promyelocytic Leukemia

Auteurs: Gurnari C, De Bellis E, Divona M, Ottone T, Lavorgna S, Voso MT
Publié dans: Chemotherapy, Numéro 64 (5-6), 2020, Page(s) 238–247, ISSN 0009-3157
Éditeur: S. Karger AG
DOI: 10.1159/000507805

The Role of the Central Limit Theorem in the Heterogeneous Ensemble of Brownian Particles Approach

Auteurs: Silvia Vitali, Iva Budimir, Claudio Runfola, Gastone Castellani
Publié dans: Mathematics, Numéro 7/12, 2019, Page(s) 1145, ISSN 2227-7390
Éditeur: MDPI
DOI: 10.3390/math7121145

Characterization of FLT3-ITDmut acute myeloid leukemia: molecular profiling of leukemic precursor cells

Auteurs: Travaglini S, Angelini DF, Alfonso V, Guerrera G, Lavorgna S, Divona M, Nardozza AM, Consalvo MI, Fabiani E, De Bardi M, Neri B, Forghieri F, Marchesi F, Paterno G, Cerretti R, Barragan E, Fiori V, Dominici S, Del Principe MI, Venditti A, Battistini L, Arcese W, Lo-Coco F, Voso MT, Ottone T.
Publié dans: Blood Cancer Journal, Numéro 10, Article number: 85, 2020, Page(s) 1-11, ISSN 2044-5385
Éditeur: Nature Publishing Group
DOI: 10.1038/s41408-020-00352-9

Impact of Concurrency on the Performance of a Whole Exome Sequencing Pipeline

Auteurs: Daniele Dall'Olio, Nico Curti, Eugenio Fonzi, Claudia Sala, Daniel Remondini, Gastone Castellani, Enrico Giampieri
Publié dans: BMC Informatics, Numéro 4, 2020, Page(s) 1-13, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.21203/rs.3.rs-16453/v1

Real-world evaluation of UK high hyperdiploidy profile using a large cohort of patients provided by HARMONY data platform

Auteurs: Amir Enshaei, Javier Martinez Elicegui, Esther Anguiano, Jude Gibson, Sulaiman Lawal, Mirella Ampatzidou, Michael Doubek, Adele K. Fielding, Edoardo La Sala, Elizabeth Middleton, Anita W. Rijneveld, Amin T. Turki, Martin Zimmermann, Ajay Vora and Anthony V. Moorman
Publié dans: Leukemia, 2023, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/s41375-023-02046-0

Random Walk Approximation for Stochastic Processes on Graphs

Auteurs: Stefano Polizzi, Tommaso Marzi, Tommaso Matteuzzi, Gastone Castellani, Armando Bazzani
Publié dans: Entropy, Numéro 25,394, 2023, Page(s) 1-23, ISSN 1099-4300
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e25030394

A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study

Auteurs: GenoMed4All consortium Giulia Maggioni Matteo Bersanelli Erica Travaglino Ana Alfonso Piérola Annika Kasprzak Arnan Sangerman Montserrat Elisabetta Sauta Claudia Sala Tommaso Matteuzzi Manja Meggendorfer Matteo Gnocchi Lin-Pierre Zhao Cristina Astrid Tentori Kathrin Nachtkamp Daniele Dall'Olio Ettore Mosca Marta Ubezio Alessia Campagna Antonio Russo Giulia Rivoli Massimo Bernardi Lorenza Borin M
Publié dans: The Lancet Haematology, Numéro VOLUME 10, ISSUE 2,, 2022, Page(s) E117-E128, ISSN 2352-3026
Éditeur: Elsevier Limited
DOI: 10.1016/s2352-3026(22)00323-4

Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY

Auteurs: Thomas Chatzikonstantinou, Lydia Scarfò, Georgios Karakatsoulis, Eva Minga, Dimitra Chamou, Gloria Iacoboni, Jana Kotaskova, Christos Demosthenous, Lukas Smolej, Stephen Mulligan, Miguel Alcoceba, Salem Al-Shemari, Thérèse Aurran-Schleinitz, Francesca Bacchiarri, Mar Bellido, Fontanet Bijou, Anne Calleja, Angeles Medina, Mehreen Ali Khan, Ramona Cassin, Sofia Chatzileontiadou, Rosa Collado, Amy
Publié dans: eClinicalMedicine, 2023, Page(s) Volume 65, Nov 2023, 102307, ISSN 2589-5370
Éditeur: Elsevier
DOI: 10.1016/j.eclinm.2023.102307

Real-World Validation of Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

Auteurs: Elisabetta Sauta , PhD1; Marie Robin, MD2; Matteo Bersanelli , PhD3; Erica Travaglino, BSc1; Manja Meggendorfer, PhD4; Lin-Pierre Zhao , MD2; Juan Carlos Caballero Berrocal, MD5; Claudia Sala , PhD6; Giulia Maggioni, MD1; Massimo Bernardi , MD7; Carmen Di Grazia, MD8; Luca Vago , MD7; Giulia Rivoli, MD8; Lorenza Borin, MD9; Saverio D'Amico , MEng1; Cristina Astrid Tentori, MD1; Marta Ubezio, MD1;
Publié dans: Journal of Clinical Oncology, Numéro Volume 41 Numéro 15, 2023, Page(s) 2827-2842, ISSN 0732-183X
Éditeur: American Society of Clinical Oncology
DOI: 10.1200/jco.22.01784

Network integration of multi-tumour omics data suggests novel targeting strategies

Auteurs: Ítalo Faria do Valle, Giulia Menichetti, Giorgia Simonetti, Samantha Bruno, Isabella Zironi, Danielle Fernandes Durso, José C. M. Mombach, Giovanni Martinelli, Gastone Castellani, Daniel Remondini
Publié dans: Nature Communications, Numéro 9/1, 2018, Page(s) 10, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-06992-7

ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation

Auteurs: Malcikova, J.; Tausch, E.; Rossi, D.; Sutton, L. A.; Soussi, T.; Zenz, T.; Kater, A. P.; Niemann, C. U.; Gonzalez, D.; Davi, F.; Gonzalez Diaz, M.; Moreno, C.; Gaidano, G.; Stamatopoulos, K.; Rosenquist, R.; Stilgenbauer, S.; Ghia, P.; Pospisilova, S.
Publié dans: "Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2018, 32 (5), pp.1070-1080. ⟨10.1038/s41375-017-0007-7⟩", Numéro 1, 2018, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.5167/uzh-151201

RNAmut: robust identification of somatic mutations in acute myeloid leukemia using RNA-seq

Auteurs: Muxin Gu, Maximilian Zwiebel, Swee Hoe Ong, Nick Boughton, Josep Nomdedeu, Faisal Basheer, Yasuhito Nannya, Pedro M. Quiros, Seishi Ogawa, Mario Cazzola, Roland Rad, Adam P. Butler, MS Vijayabaskar, George Vassiliou
Publié dans: Haematologica, 2019, Page(s) haematol.2019.230821, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.230821

Frailness and resilience of gene networks predicted by detection of co-occurring mutations via a stochastic perturbative approach

Auteurs: Matteo Bersanelli, Ettore Mosca, Luciano Milanesi, Armando Bazzani, Gastone Castellani
Publié dans: Scientific Reports, Numéro 10/1, 2020, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-020-59036-w

BRAQUE: Bayesian Reduction for Amplified Quantization in UMAP Embedding

Auteurs: by Lorenzo Dall’Olio, ,Maddalena Bolognesi ,Simone Borghesi ,Giorgio Cattoretti and Gastone Castellani
Publié dans: Entropy, Numéro 25, 354, 2023, Page(s) 1-23, ISSN 1099-4300
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/e25020354

Additional file 2 of Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting

Auteurs: Lang, Katharina M.; Harrison, Kathryn L.; Williamson, Paula R.; Huntly, Brian J. P.; Ossenkoppele, Gert; Geissler, Jan; Tamàs Bereczky; Hernández-Rivas, Jesús M.; Chevrou-Séverac, Hélène; Goodbody, Rory; Schulze-Rath, Renate; Bullinger, Lars
Publié dans: Trials, Numéro 21/1, 2020, ISSN 1745-6215
Éditeur: BioMed Central
DOI: 10.6084/m9.figshare.12381656

Characterization and comparison of gene-centered human interactomes

Auteurs: Ettore Mosca, Matteo Bersanelli, Tommaso Matteuzzi, Noemi Di Nanni, Gastone Castellani, Luciano Milanesi, Daniel Remondini,
Publié dans: Briefings in Bioinformatics, Numéro Volume 22, Numéro 6,, 2021, Page(s) 1-16, ISSN 1467-5463
Éditeur: Oxford University Press
DOI: 10.1093/bib/bbab153

Building a Healthcare Alliance for Resourceful Medicine Offensive Against Neoplasms in HematologY Added Value Framework for Hematologic Malignancies: A Comparative Analysis of Existing Tools

Auteurs: Francesco Cerisoli,Farzad Ali,Tamás Bereczky,Natacha Bolaños,Lars Bullinger,Sujith Dhanasiri,James Gallagher,Sonia García Pérez,Jan Geissler,Yann Guillevic,Kathryn Harrison,Anastasia Naoum,Carla Portulano,Ana E. Rodríguez Vicente et al.
Publié dans: Value in Health, Numéro 18 May 2022, 2022, ISSN 1098-3015
Éditeur: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2022.04.1729

Are next-generation sequencing results knocking on Heaven’s door for transplantation planning in chronic myelomonocytic leukemia?

Auteurs: Guillermo F. Sanz, Mariam Ibañez, Elvira Mora
Publié dans: Haematologica, Numéro Vol. 105 No. 3 (2020): March, 2020, 2020, Page(s) 530-533, ISSN 0390-6078
Éditeur: Ferrata Storti Foundation
DOI: 10.3324/haematol.2019.240853

Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia

Auteurs: Fabiani E, Cicconi L, Nardozza AM, Cristiano A, Rossi M, Ottone T, Falconi G, Divona M, Testi AM, Annibali O, Castelli R, Lazarevic V, Rego E, Montesinos P, Esteve J, Venditti A, Della Porta M, Arcese W, Lo-Coco F, Voso MT
Publié dans: Cancer Medicine, Numéro 10(12), 2021, Page(s) 3839-3847, ISSN 2045-7634
Éditeur: John Wiley & Sons.
DOI: 10.1002/cam4.3904

Second Revision of the International Staging System (R2-ISS) for Overall Survival in Multiple Myeloma: A European Myeloma Network (EMN) Report Within the HARMONY Project

Auteurs: Mattia D’Agostino; David A. Cairns; Juan Jose Lahuerta; Ruth Wester; Uta Bertsch; Anders Waage; Elena Zamagni; Maria-Victoria Mateos; Daniele Dall’Olio; Niels W.C.J. van de Donk; Graham Jackson; Serena Rocchi; Hans Salwender; Joan Blade Creixenti; Bronno van der Holt; Gastone Castellani; Francesca Bonello; Andrea Capra; Elias K. Mai; Jan Durig; Francesca Gay; Sonja Zweegman; Michele Cavo,; Mar
Publié dans: J Clin Oncol . 2022 May 23;JCO2102614, Numéro May 23, 2022, 2022, ISSN 1527-7755
Éditeur: Lippincott Williams & Wilkins
DOI: 10.1200/jco.21.02614

A network approach for low dimensional signatures from high throughput data

Auteurs: Nico Curti, Giuseppe Levi, Enrico Giampieri, Gastone Castellani & Daniel Remondini
Publié dans: Scientific reports, Numéro 12, 2022, Page(s) 1-9, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-25549-9

Classification and Personalized Prognostic Assessment on the Basis of Clinical and Genomic eatures in Myelodysplastic Syndromes

Auteurs: Matteo Bersanelli, Erica Travaglino, Manja Meggendorfer, Tommaso Matteuzzi, Claudia Sala, Ettore Mosca, Chiara Chiereghin, Noemi Di Nanni, Matteo Gnocchi, Matteo Zampini, Marianna Rossi, Giulia Maggioni, Alberto Termanini, Emanuele Angelucci, Massimo Bernardi, Lorenza Borin, Benedetto Bruno, Francesca Bonifazi, Valeria Santini, Andrea Bacigalupo, Maria Teresa Voso, Esther Oliva, Marta Riva, Marta
Publié dans: Journal of Clinical Oncology, Numéro 39, no. 11, 2021, Page(s) 1223-1233, ISSN 0732-183X
Éditeur: American Society of Clinical Oncology
DOI: 10.1200/jco.20.01659

Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico-biological parameters

Auteurs: Carmelo Gurnari, Massimo Breccia, Francesca Di Giuliano, Emilia Scalzulli, Mariadomenica Divona, Alfonso Piciocchi, Laura Cicconi, Eleonora De Bellis, Adriano Venditti, Maria Ilaria Del Principe, William Arcese, Francesco Lo-Coco, Francesco Garaci, Maria Teresa Voso
Publié dans: British Journal of Haematology, Numéro 193 (1), 2021, Page(s) 129-132, ISSN 1365-2141
Éditeur: Wiley
DOI: 10.1111/bjh.17018

Core outcome set measurement for future clinical trials in acute myeloid leukemia: the HARMONY study protocol using a multi-stakeholder consensus-based Delphi process and a final consensus meeting

Auteurs: Katharina M. Lang, Kathryn L. Harrison, Paula R. Williamson, Brian J. P. Huntly, Gert Ossenkoppele, Jan Geissler, Tamàs Bereczky, Jesús M. Hernández-Rivas, Hélène Chevrou-Séverac, Rory Goodbody, Renate Schulze-Rath, Lars Bullinger
Publié dans: Trials, Numéro 21/1, 2020, ISSN 1745-6215
Éditeur: BioMed Central
DOI: 10.1186/s13063-020-04384-1

Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY

Auteurs: Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Georgios Karakatsoulis, Manja Meggendorfer, Helen Parker, Ferran Nadeu, Christian Brieghel, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E. Rodríguez-Vicente, Rocío Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagio
Publié dans: Leukemia, Numéro 37, 2023, Page(s) 339 – 347, ISSN 0887-6924
Éditeur: Nature Publishing Group
DOI: 10.1038/s41375-022-01802-y

Unified classification and risk-stratification in Acute Myeloid Leukemia

Auteurs: Tazi Y, Arango-Ossa JE, Zhou Y, Bernard E, Thomas I, Gilkes A, Freeman S, Pradat Y, Johnson SJ, Hills R, Dillon R, Levine MF, Leongamornlert D, Butler A, Ganser A, Bullinger L, Döhner K, Ottmann O, Adams R, Döhner H, Campbell PJ, Burnett AK, Dennis M, Russell NH, Devlin SM, Huntly BJP, Papaemmanuil E.
Publié dans: Nature Communications, Numéro 13(1): 4622, 2022, Page(s) 1-16, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-022-32103-8

Long-Term Follow-up of AML Patients Treated Intensively before the Era of Targeted Agents. a Big Data Analysis from the Harmony Collaboration

Auteurs: Marta Anna Sobas, Angela Villaverde Ramiro, Alberto Hernández Sánchez, Javier Martinez Elicegui, Teresa González, Raúl Azibeiro Melchor, María Abáigar, Laura Tur, Daniele Dall'Olio, Eric Sträng, Jesse M. Tettero, Castellani Gastone, Axel Benner, Konstanze Döhner, Christian Thiede, Amin T. Turki, Klaus H. Metzeler, Torsten Haferlach, Frederick Damm, Rosa Ayala, Joaquín Martínez-López, Ke
Publié dans: Blood, Numéro 140 (Supplement 1), 2022, Page(s) 6053–6055, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2022-165088

Pan-Stakeholder Core Outcome Set (COS) Definition for Selected Hematological Malignancies - Results of the Harmony Alliance

Auteurs: Katharina M Lang, Tamás Bereczky, Natacha Bolanos, Ana Vallejo, Ananda Plate, Kathryn E. Morgan, Sophie Wintrich, Nick York, Gert J. Ossenkoppele, Brian J.P Huntly, Hartmut Döhner, Gilles Salles, Martin H. Dreyling, Silvia Montoto, Pieter Sonneveld, Jesus San-Miguel, Mario Boccadoro, Pierre Fenaux, Andrea Kündgen, Valeria Santini, Paolo Ghia, Sarka Pospisilova, Francesc Bosch, Katy Harrison, Ja
Publié dans: Blood, Numéro 138 (Supplement 1), 2021, Page(s) 5031, ISSN 1528-0020
Éditeur: Elsevier
DOI: 10.1182/blood-2021-145002

POSA22 Do We Need to Mind the Gap: An Analysis of the Evidence Base Differences and Alignment across Regulator and HTA Agencies

Auteurs: K Harrison D O'Rourke P Jonsson
Publié dans: Value in Health, 2021, Page(s) S21-S22
Éditeur: Elsevier
DOI: 10.1016/j.jval.2021.11.096

IKZF1 Deletions Are Markers of Treatment Resistance in Adult Ph-Negative B-Cell Acute Lymphoblastic Leukemia Patients Treated within the Ongoing Risk-Adapted Pethema LAL19 Trial

Auteurs: Jordi Ribera, Isabel Granada, Teresa González, Mireia Morgades, Olga Garcia, Ricardo Sanchez, Esperanza Such, Susana Barrena, Juana Ciudad, Beatriz Soriano, Rocio Benito, Gayane Avetisyan, Eva Lumbreras, Cristina Miguel-García, Sandra Santos-Mínguez, Lurdes Zamora, Mar Mallo, Celia González-Gil, Eulàlia Genescà, Thaysa Lopes, Jesus Maria Hernández-Rivas, Alberto Orfao, Josep-Maria Ribera
Publié dans: Blood, Numéro 140 (Supplement 1), 2022, Page(s) 6345–6347, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2022-162159

Does RAD21 Co-Mutation Have a Role in DNMT3A Mutated AML? Results of Harmony Alliance AML Database

Auteurs: Raúl Azibeiro Melchor, Alberto Hernández Sánchez, Teresa González, Marta Sobas, Javier Martinez Elicegui, Angela Villaverde Ramiro, Axel Benner, Eric Sträng, Castellani Gastone, Caroline A. Heckman, Ana Heredia Casanoves, Jurjen Versluis, María Abáigar, Laura Jamilis, Peter JM Valk, Klaus H. Metzeler, Rosa Ayala, Herve Dombret, Jorge Sierra, Claude Preudomme, Frederick Damm, Ken I Mills, Ji
Publié dans: Blood, Numéro 138 (Supplement 1), 2021, Page(s) 608, ISSN 1528-0020
Éditeur: Elsevier
DOI: 10.1182/blood-2021-150766

Rearrangements Involving 11q23/KMT2A: Mutational Landscape and Prognostic Implications - Results of the Harmony Alliance AML Database

Auteurs: Alberto Hernández Sánchez, Teresa González, Marta Anna Sobas, Eric Sträng, Castellani Gastone, María Abáigar, Peter JM Valk, Angela Villaverde Ramiro, Axel Benner, Klaus H. Metzeler, Jesse M. Tettero, Joaquín Martínez-López, Marta Pratcorona, Javier Martinez Elicegui, Ken I Mills, Christian Thiede, Guillermo Sanz, Konstanze Döhner, Michael Heuser, Torsten Haferlach, Amin T. Turki, Dirk R
Publié dans: Blood, Numéro 140 (Supplement 1), 2022, Page(s) 551–554, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2022-167480

R2-ISS, A new Risk Stratification Model in newly diagnosed multiple myeloma (NDMM): Analysis of 7077 patient data by the European Myeloma Network (EMN) within HARMONY Big Data Platform project

Auteurs: M. D’Agostino, J.J. Lahuerta, R. Wester, A. Waage, U. Bertsch,E. Zamagni, M.V. Mateos, A. Larocca, D. Dall’Olio, N.W.C.J. van de Donk, D. Cairns, S. Rocchi, H. Salwender, J. Bladé, B. van der Holt, G. Castellani, G. Ciccone, A. Capra, J. Dürig, S. Bringhen, S. Zweegman, M. Cavo, H. Goldschmidt, G. Cook, J.M. Hernandez Rivas, J. San-Miguel, M. Boccadoro, P. Sonneveld
Publié dans: HAEMATOLOGICA, Numéro Vol. 106 No. s3, 2021, Page(s) 12-13, ISSN 0390-6078
Éditeur: Ferrata-Storti Foundation
DOI: 10.3324/haematol.2021.s3

A New Risk Stratification Model (R2-ISS) in Newly Diagnosed Multiple Myeloma: Analysis of Mature Data from 7077 Patients Collected By European Myeloma Network within Harmony Big Data Platform

Auteurs: Mattia D'Agostino, Juan-José Lahuerta, Ruth Wester, Anders Waage, Uta Bertsch, Elena Zamagni, Maria-Victoria Mateos, Alessandra Larocca, Daniele Dall'Olio, Niels W. C. J. van de Donk, David Cairns, Serena Rocchi, Hans Salwender, Joan Blade Creixenti, Bronno van der Holt, Castellani Gastone, Giovannino Ciccone, Andrea Capra, Jan Dürig, Sara Bringhen, Sonja Zweegman, Michele Cavo, Hartmut Goldschm
Publié dans: Blood, Numéro 136/Supplement 1, 2020, Page(s) 34-37, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2020-137021

Harmony Alliance Provides a Machine Learning Researching Tool to Predict the Risk of Relapse after First Remission in AML Patients Treated without Allogeneic Haematopoietic Stem Cell transplantation

Auteurs: Marta Sobas, Javier Martinez Elicegui, Angela Villaverde Ramiro, Teresa González, Alberto Hernandez-Sanchez, Raúl Azibeiro Melchor, Axel Benner, Eric Sträng, Castellani Gastone, Caroline A. Heckman, Ana Heredia Casanoves, Jurjen Versluis, María Abáigar, Laura Jamilis, Peter JM Valk, Klaus H. Metzeler, Rosa Ayala, Joaquin Martinez Lopez, Hervé Dombret, Jorge Sierra, Claude Preudomme, Frederic
Publié dans: Blood, Numéro 138 (Supplement 1), 2021, Page(s) 4041, ISSN 1528-0020
Éditeur: Elsevier
DOI: 10.1182/blood-2021-149521

Machine Learning Allows the Identification of New Co-Mutational Patterns with Prognostic Implications in NPM1 Mutated AML - Results of the European Harmony Alliance

Auteurs: Alberto Hernández Sánchez, Angela Villaverde Ramiro, Eric Sträng, Castellani Gastone, Caroline A. Heckman, Jurjen Versluis, María Abáigar, Marta Anna Sobas, Raúl Azibeiro Melchor, Axel Benner, Peter JM Valk, Klaus H. Metzeler, Teresa González, Daniele Dall'Olio, Jesse M. Tettero, Javier Martinez Elicegui, Joaquín Martínez-López, Marta Pratcorona, Frederik Damm, Ken I Mills, Christian Thi
Publié dans: Blood, Numéro 140 (Supplement 1), 2022, Page(s) 739–742, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2022-167138

NPM1 MUTATED AML: IMPACT OF CO-MUTATIONAL PATTERNS - RESULTS OF THE EUROPEAN HARMONY ALLIANCE

Auteurs: Alberto Hernández-Sánchez, Ángela Villaverde-Ramiro, Javier Martínez Elicegui, Teresa González, Axel Benner, Eric Sträng, Gastone Castellani, Caroline A. Heckman, Jurjen Versluis, María Abáigar, Marta Sobas, Raúl Azibeiro, Laura Tur, Peter JM Valk, Klaus H Metzeler, Rosa Ayala, Daniele Dall'Olio, Jesse Tettero, Joaquín Martínez-López, Hervé Dombret, Marta Pratcorona, Frederik Damm, Ke
Publié dans: HemasSphere, 2022, Page(s) 61-65, ISSN 2572-9241
Éditeur: LWW Journals - Wolters Kluwer
DOI: 10.1097/01.hs9.0000852292.38263.b8

Abstract Book: 25th Congress of the European Hematology Association Virtual Edition, 2020

Auteurs: "1.Bullinger, L. et al. NOVEL INSIGHTS INTO GENOMIC CLASSIFICATION AND PROGNOSIS IN ACUTE MYELOID LEUKEMIA BASED ON A PAN-EUROPEAN PUBLICPRIVATE PARTNERSHIP, THE HARMONY ALLIANCE. [Abstract #S130, EHA 2020 25th Congress]. Oral Presentation. HemaSphere, 4(S1), 16, http://dx.doi.org/10.1097/HS9.0000000000000404 2. Jordi Ribera, Jesús María Hernández-Rivas, Josep Maria Ribera. PROGNOSTIC SIGNIFICAN"
Publié dans: HemaSphere, Numéro 4/S1, 2020, Page(s) 1-1168, ISSN 2572-9241
Éditeur: LWW Journals - Wolters Kluwer
DOI: 10.1097/hs9.0000000000000404

Robust Validation of the UKALL High Hyperdiploid Risk Profile Using Individual Patient Data Collected By the Harmony Alliance

Auteurs: Amir Enshaei, Javier Martinez Martínez Elicegui, Esther Anguiano, Jude Gibson, Mirella Ampatzidou, Michael Doubek, Adele K. Fielding, Edoardo La Sala, Elizabeth Middleton, Anita W. Rijneveld, Amin T. Turki, Ajay Vora, Martin Zimmermann, Anthony V. Moorman
Publié dans: Blood, Numéro 140 (Supplement 1), 2022, Page(s) 6369–6370, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2022-157680

PRO16 Mapping and Understanding Uncertainties That Arise in the HTA Evidence Base for Haematological Malignancies: A PAN-Jurisdiction Study

Auteurs: D. O'Rourke and K. Harrison
Publié dans: Value in Health, Numéro VOLUME 23, SUPPLEMENT 2, 2020, Page(s) S692, ISSN 1098-3015
Éditeur: Elsevier
DOI: 10.1016/j.jval.2020.08.1752

Statistical modelling of CG interdistance across multiple organisms

Auteurs: Merlotti A., Faria do Valle I., Castellani G., Remondini D.
Publié dans: BMC Bioinformatics, Numéro 19/S10, 2018, Page(s) 7, ISSN 1471-2105
Éditeur: BioMed Central
DOI: 10.1186/s12859-018-2303-2

HARMONY ALLIANCE: EUROPEAN PUBLIC-PRIVATE DATA COLLECTION LEADS THE WAY - FIRST RESULTS OF THE “PROOF-OF-PRINCIPLE” STUDY IN ACUTE MYELOID LEUKEMIA

Auteurs: L. Bullinger, P. Valk, J. Versluis, K. Metzeler, R. Ayala, Martinez J. Lopez, H. Dombret, P. Montesinos, J. Sierra, C. Preudhomme, F. Damm, K. Mills, J. Mayer, C. Thiede, M. T. Voso, S. Amadori, W. Hiddemann, G. Sanz, M. Vukcevic, P. Bacon, Villoria R. Medina, M. Van Speybroeck, R. Goodbody, R. Schulze-Rath, J.-E. Butler-Ransohoff, J. M. Hernández, F. Lo-Coco, B. Huntly, H. Döhner, G. Ossenkoppe
Publié dans: HemaSphere, Numéro 3, 2019, Page(s) 451, ISSN 2572-9241
Éditeur: Lippincott Williams & Wilkins (LWW)
DOI: 10.1097/01.hs9.0000562308.58356.23

Validation and Improvement Opportunities of the Revised International Staging System for Multiple Myeloma: An Analysis on Mature Data from European Clinical Trials within the Harmony Big Data Platform

Auteurs: Mattia D'Agostino, Anders Waage, Juan-José Lahuerta, Uta Bertsch, Elena Zamagni, Lars Bullinger, Alessandra Larocca, Maria-Victoria Mateos, Niels W. C. J. Van De Donk, Hans Jürgen Salwender, Joan Bladé, Bronno van der Holt, Paola Tacchetti, Giovannino Ciccone, Sonja Zweegman, Hartmut Goldschmidt, Michele Cavo, Jesús San-Miguel, Pieter Sonneveld, Mario Boccadoro, Jesús María Hernández-Rivas
Publié dans: Blood, Numéro 134/Supplement_1, 2019, Page(s) 1773-1773, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2019-124321

PCV156 A MULTILEVEL ACCESS EVIDENCE FRAMEWORK FOR INNOVATIVE TECHNOLOGIES SPECIFIC TO HAEMATOLOGICAL MALIGNANCIES

Auteurs: Harrison, K. O'Rourke, D.Chevrou-Severac, H. Gaudig, M. Collados, C. Wirtz, D. Conge, M. Garcia-Perez, S. Lee, A. Jonsson, P.
Publié dans: Value in Health, Numéro Value in Health, 2019, Page(s) S571
Éditeur: Elsevier
DOI: 10.1016/j.jval.2019.09.880

EHA2021 Virtual Congress Abstract BookEP631 OTHER MALIGNANCIES IN THE HISTORY OF CHRONIC LYMPHOCYTIC LEUKEMIA -, A RETROSPECTIVE, MULTICENTRE COHORT STUDY BY ERIC, THE EUROPEAN RESEARCH INITIATIVE ON CLL IN HARMONY. Abstract S143 CLINICAL IMPACT OF RECURRENT GENE MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA: A RETROSPECTIVE, MULTI-CENTER COHORT STUDY BY ERIC, THE EUROPEAN RESEARCH INITIATIVE ON C

Auteurs: T. Chatzikonstantinou 1,2,*, L. Scarfò 1,3, J. Kotašková 4,5, G. Iacoboni 6, E. Minga 2, D. Chammou 2, G. Karakatsoulis 2, M. Alcoceba 7, S. El-Ashwah 8, F. Bacchiarri 9, M. Ali Khan 10, R. Cassin 11, S. Chatzileontiadou 12, A. Christian 13, R. Collado 14, M. D. De Deus Santos 15, Z. Davis 13, C. Demosthenous 16, M. Dimou 17, D. Donaldson 18, G. Dos Santos 19, B. Dreta 20, M. Efstathopoulou 21,
Publié dans: Hemasphere, Numéro Volume 5 - Numéro - p e566, 2021, Page(s) 25, ISSN 2572-9241
Éditeur: Wolters Kluwer Health
DOI: 10.1097/hs9.0000000000000566

Different Prognostic Impact of Recurrent Gene Mutations in IGHV-Mutated and IGHV-Unmutated Chronic Lymphocytic Leukemia: A Retrospective, Multi-Center Cohort Study By Eric, the European Research Initiative on CLL, in Harmony

Auteurs: Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Manja Meggendorfer, Ferran Nadeu, Christian Brieghel, Helen Parker, Stamatia Laidou, Riccardo Moia, Davide Rossi, Mark Catherwood, Jana Kotaskova, Julio Delgado, Ana E Rodríguez-Vicente, Rocio Benito, Gian Matteo Rigolin, Silvia Bonfiglio, Lydia Scarfo, Mattias Mattsson, Zadie Davis, Ajay Gogia, Lata Rani, Panagiotis Baliakas, Cecilia Jylh
Publié dans: Blood, Numéro 138 (Supplement 1), 2021, Page(s) 2617, ISSN 1528-0020
Éditeur: Elsevier
DOI: 10.1182/blood-2021-150648

POSA269 Above and Beyond: Assessing the Nature and Impact of Additional Considerations Above Clinical and Cost Effectiveness by 8 HTA Agencies for a Rare Disease Area

Auteurs: K Harrison D O'Rourke P Jonsson
Publié dans: Value in Health, 2021, Page(s) S172
Éditeur: Elsevier
DOI: 10.1016/j.jval.2021.11.836

Pan-Stakeholder Core Outcome Set (COS) Definition for Hematological Malignancies within the Framework of Harmony and Harmony PLUS Projects

Auteurs: Katharina M Lang, Tamás Bereczky, Jan Geissler, Natacha Bolanos, Kathryn E. Morgan, Ananda Plate, Ana Vallejo, Sophie Wintrich, Nick York, Peter Loffelhardt, Brian Huntly, Pieter Sonneveld, Mario Boccadoro, Valeria Santini, Šárka Pospíšilová, Andreas Hochhaus, Tiziano Barbui, Peter Borchmann, Christian Buske, Yann Guillevic, Frederico Calado, Katy Harrison, Dalia Dawoud, Guillermo Sanz, Jes
Publié dans: Blood, Numéro 140 (Supplement 1), 2022, Page(s) 5285–5287, ISSN 0006-4971
Éditeur: American Society of Hematology
DOI: 10.1182/blood-2022-157549

Impact of Gender on Molecular AML Subclasses - a Harmony Alliance Study

Auteurs: Tommaso Matteuzzi, Daniele Dall'Olio, Eric Sträng, Alessandra Merlotti, Javier Martinez Elicegui, Axel Benner, Maral Saadati, Julia Krzykalla, Caroline A. Heckman, Ana Heredia Casanoves, Jurjen Versluis, María Abáigar, Alberto Hernandez-Sanchez, Laura Jamilis, Peter JM Valk, Klaus H. Metzeler, Rosa Ayala, Joaquin Martinez Lopez, Herve Dombret, Pau Montesinos, Jorge Sierra, Claude Preudomme, Fre
Publié dans: Blood, Numéro 138 (Supplement 1), 2021, Page(s) 3438, ISSN 1528-0020
Éditeur: Elsevier
DOI: 10.1182/blood-2021-152215

Harnessing Big Data in Treating Hematologic Malignancies

Auteurs: Sarah LaCorte
Publié dans: Oncology Times, 2020, ISSN 1548-4688
Éditeur: Publisher Lynn Nace
DOI: 10.1097/01.cot.0000668176.71146.93

DNetPRO: A network approach for low-dimensional signatures from high-throughput data

Auteurs: Curti, Nico; Giampieri, Enrico; Levi, Giuseppe; Castellani, Gastone; Remondini, Daniel
Publié dans: bioRxiv, Numéro 1, 2019, ISSN 2692-8205
Éditeur: bioRxiv
DOI: 10.1101/773622

BIG DATA FOR BETTER OUTCOMES: SUPPORTING HEALTH CARE SYSTEM TRANSFORMATION IN EUROPE

Auteurs: Miklós Szócska, Sahan Jayawardana, Carin Smand, Tayyab Salimullah, Catherine Reed and Shahid Hanif
Publié dans: Eurohealth — Vol.23 | No.1 | 2017, 2017, ISSN 1356-1030
Éditeur: LSE Health and the European Observatory on Health Systems and Policies

Hematology and Big Data

Auteurs: Ellen P.B. de Waal
Publié dans: HemaSphere, Numéro 1/1, 2017, Page(s) e17, ISSN 2572-9241
Éditeur: Daniel Hyde
DOI: 10.1097/hs9.0000000000000017

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Healthcare Alliance for Resourceful Medicines Offensive against Neoplasms in HematologY - Sofia ref.: 116026

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