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Translational quantitative systems toxicology to improve the understanding of the safety of medicines - Sofia: 116030

Objective

TransQST will develop a Quantitative Systems Toxicology (QST) approach, employing pre-existing data where possible, in order to yield new mechanistic insight into drug-induced toxicity. A central tenet of our programme will be to ensure the human physiological and pharmacological relevance of any test system that has been (or will be) used for generating the input data for modelling. By adopting this approach, we will be able to accurately interpret what happens when test systems are perturbed by drug exposure, and ensure translatability of modelling tools. Mechanistic translational biomarkers are a core aspect of our approach and will be applied in parallel with evidence for understanding how to develop, model and apply such biomarkers in a QST setting. The project is structured in 8 work packages to provide the following outcomes: curate the best available experimental data suitable for modelling adverse drug reactions; provide fit-for-purpose QST models that will address key toxicity measures for liver, kidney, heart and GI-tract; provide quantitative risk assessment for off-target toxicity in man based on in vitro and in vivo models; provide a quantitative mechanistic read-across from species (in vivo and in vitro) currently used for the toxicological evaluation of a new drug; provide definition and applicability of the human physiological relevance of preclinical test systems; provide a battery of translational biomarkers that can be used for quantitative read-across from in vitro systems to man and which relate to intracellular pathways (and systems) relevant to drug toxicity. Led by the University of Liverpool, TransQST brings together 14 partners, characterized by their scientific rigour and proven track record. Collectively they will enable achievement of the goals of the call, thanks to their complementarity, proven ability to work together (and with EFPIA partners), and their understanding of how to ensure the relevance of QST to human biology.

Coordinator

THE UNIVERSITY OF LIVERPOOL
Net EU contribution
€ 1 161 913,75
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
United Kingdom

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Region
North West (England) Merseyside Liverpool
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (22)

UNIVERSITEIT LEIDEN
Netherlands
Net EU contribution
€ 1 276 662,50
Address
Rapenburg 70
2311 EZ Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 16 000,00
FUNDACIO INSTITUT HOSPITAL DEL MAR D INVESTIGACIONS MEDIQUES
Spain
Net EU contribution
€ 900 525,00
Address
Doctor Aiguader 88
08003 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SYNAPSE RESEARCH MANAGEMENT PARTNERS SL
Spain
Net EU contribution
€ 353 668,75
Address
Calle Velazquez 94 Planta 1
28006 Madrid

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 25 000,00
UNIVERSITEIT MAASTRICHT
Netherlands
Net EU contribution
€ 793 300,00
Address
Minderbroedersberg 4
6200 MD Maastricht

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Region
Limburg (NL) Zuid-Limburg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Net EU contribution
€ 1 093 088,75
Address
Meyerhofstrasse 1
69117 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 325 000,00
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CERTARA UK LIMITED
United Kingdom
Net EU contribution
€ 484 600,00
Address
One London Wall 6th Floor
EC2Y 5EB London

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Region
London Inner London — West Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITAT WIEN
Austria
Net EU contribution
€ 350 250,00
Address
Universitatsring 1
1010 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSKLINIKUM AACHEN

Participation ended

Germany
Net EU contribution
€ 132 435,00
Address
Pauwelsstrasse 30
52074 Aachen

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Region
Nordrhein-Westfalen Köln Städteregion Aachen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EV
Germany
Net EU contribution
€ 350 250,00
Address
Ardeystrasse 67
44139 Dortmund

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Region
Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OCELLO BV
Netherlands
Net EU contribution
€ 288 016,25
Address
J H Oortweg Leiden Biopartner 21
2333 CH Leiden

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 220 500,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ABBVIE DEUTSCHLAND GMBH & CO KG
Germany
Net EU contribution
€ 0,00
Address
Mainzer Str. 81
65205 Wiesbaden

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Region
Darmstadt Wiesbaden, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 245 000,00
ELI LILLY AND COMPANY LTD
United Kingdom
Net EU contribution
€ 0,00
Address
Lilly House Basingview
RG21 4FA Basingstoke

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Region
South East (England) Hampshire and Isle of Wight North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 320 000,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 251 874,00
ASTRAZENECA AB
Sweden
Net EU contribution
€ 0,00
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 001 000,00
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Net EU contribution
€ 0,00
Address
Great West Road 980
TW89GS Brentford

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Region
London Outer London — West and North West Hounslow and Richmond upon Thames
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 934 000,00
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
France
Net EU contribution
€ 0,00
Address
Rue Carnot 50
92284 Courbevoie

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Region
Ile-de-France Ile-de-France Hauts-de-Seine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 668 750,00
JANSSEN PHARMACEUTICA NV
Belgium
Net EU contribution
€ 0,00
Address
Turnhoutseweg 30
2340 Beerse

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Region
Vlaams Gewest Prov. Antwerpen Arr. Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 250 000,00
ORION OYJ
Finland
Net EU contribution
€ 0,00
Address
Orionintie 1
02200 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 116 250,00
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Net EU contribution
€ 0,00
Address
Binger Strasse
55218 Ingelheim

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 500 000,00
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
Net EU contribution
€ 269 790,00
Address
Im Neuenheimer Feld 672
69120 Heidelberg

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Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00