Objective
The mechanisms involved in innate immune responses against pathogens are strikingly conserved during evolution. In plants, as well as in mammals, the innate immune system achieves its role of defence against pathogens through the use of specific pathogen r ecognition receptors, all containing a conserved LRR domain involved directly in pathogen-associated molecular pattern recognition. In mammals, transmembrane receptors associated with pathogen recognition are well described, but the existence of intracellu lar pathogen receptors is just emerging, with the recent description of a new family of human intracellular LRR domain containing proteins named CATERPILLER. These proteins are expected to play key roles in immune responses against pathogens, but to date, their roles are still poorly defined. Here, we propose to study one of these putative intracellular pathogen receptor, NALP3, which is implicated in three human dominantly-inherited inflammatory syndromes. We plan to 1) characterise the tissue specificity of Nalp3 expression in mice, and 2) use in vivo models consisting of Nalp3-deficient mice and NALP3 transgenic mice overexpressing the human wild-type or mutated proteins, to gain insight into 2.1) the role of Nalp3 protein in the mouse innate immunity, 2. 2) the mechanisms involved in intracellular pathogen recognition and 2.3) the role of the human NALP3 protein and its involvement in inherited inflammatory disorders.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkali metals
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
- natural sciences computer and information sciences artificial intelligence pattern recognition
- natural sciences biological sciences zoology mammalogy
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EPALINGES
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.