In vivo analysis of NALP3, a protein implicated in three dominantly inherited syndromes, using knock-out and transgenic mice models

Información del proyecto

NALP3 IN IMMUNITY

Identificador del acuerdo de subvención: 11605

Proyecto cerrado

Fecha de inicio 1 Junio 2005

Fecha de finalización 31 Mayo 2007

Financiado con arreglo a

• Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Coste total Sin datos

Aportación de la UE € 143 453,00

Coordinado por

UNIVERSITY OF LAUSANNE, DEPARTMENT OF BIOCHEMISTRY
Switzerland

Objetivo

The mechanisms involved in innate immune responses against pathogens are strikingly conserved during evolution. In plants, as well as in mammals, the innate immune system achieves its role of defence against pathogens through the use of specific pathogen r ecognition receptors, all containing a conserved LRR domain involved directly in pathogen-associated molecular pattern recognition. In mammals, transmembrane receptors associated with pathogen recognition are well described, but the existence of intracellu lar pathogen receptors is just emerging, with the recent description of a new family of human intracellular LRR domain containing proteins named CATERPILLER. These proteins are expected to play key roles in immune responses against pathogens, but to date, their roles are still poorly defined. Here, we propose to study one of these putative intracellular pathogen receptor, NALP3, which is implicated in three human dominantly-inherited inflammatory syndromes. We plan to 1) characterise the tissue specificity of Nalp3 expression in mice, and 2) use in vivo models consisting of Nalp3-deficient mice and NALP3 transgenic mice overexpressing the human wild-type or mutated proteins, to gain insight into 2.1) the role of Nalp3 protein in the mouse innate immunity, 2. 2) the mechanisms involved in intracellular pathogen recognition and 2.3) the role of the human NALP3 protein and its involvement in inherited inflammatory disorders.

Ámbito científico (EuroSciVoc)

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véase: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• ciencias naturales › ciencias químicas › química inorgánica › metales alcalinos
• ciencias naturales › ciencias biológicas › bioquímica › biomoléculas › proteínas
• ciencias médicas y de la salud › medicina básica › inmunología
• ciencias naturales › informática y ciencias de la información › inteligencia artificial › reconocimiento de patrones
• ciencias naturales › ciencias biológicas › zoología › mamalogía

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Palabras clave

• Innate immunity
• NALP3
• human disease
• mutation
• pathogen receptor

Programa(s)

• FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006

Tema(s)

• MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF)

Convocatoria de propuestas

FP6-2002-MOBILITY-5
Consulte otros proyectos de esta convocatoria

Régimen de financiación

EIF - Marie Curie actions-Intra-European Fellowships

Coordinador

UNIVERSITY OF LAUSANNE, DEPARTMENT OF BIOCHEMISTRY

• Aportación de la UE: Sin datos
• Dirección: Chemin des Boveresses 155 ; EPALINGES ; Suiza
• Coste total: Sin datos