Objective The main objective of the project is the development of a protocol capable of identifying i) novel drug binding sites and ii) novel drug-protein complexes of Mycobacterium tuberculosis proteins. Our present knowledge of human genomics and proteomics a llows possible new approaches in drug discovery, motivated by combinatorics-based data-mining and knowledge discovery techniques, sometimes labelled as "high throughput" techniques. Solely these approaches (without sound biological background) seem to be still inadequate for drug discovery. In the present project we aim to develop a protocol, rather than a software with two ingredients: a, A method, with an algorithmic solution in its centre, which identifies surface indentation patterns in protein 3 D structures. Using very high throughput methods based on recent result of data mining and information retrieval, pairwise searches will be conducted to predicate drug-protein binding in two main phases, a rough first phase (Silico 1) and a more thoroug h docking investigation (Silico 2) in the second phase. b, A structural and molecular biology protocol for examining the most promising drug-protein fit pairs with a variety of medium throughput and low throughput methods. Fields of science medical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacy Keywords clustering techniques data mining biochemical databases high throughput techniques similarity search Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-2.3.0-1 - Highly innovative approaches for the development of new interventions for HIV, malaria and tuberculosis Call for proposal FP6-2003-LIFESCIHEALTH-3 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator EOTVOS LORAND TUDOMANYEGYETEM Address Egyetem ter 1-3 Budapest Hungary See on map Links Website Opens in new window EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all MTA ENZIMOLOGIAI KUTATOINTEZET Hungary EU contribution € 0,00 Address Karolina ut 29-31 Budapest See on map Links Website Opens in new window UNIVERSITY OF MESSINA Italy EU contribution € 0,00 Address C. da papardo s. ta sperone 31 Messina See on map Links Website Opens in new window EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 0,00 Address Meyerhofstrasse 1 Heidelberg See on map Links Website Opens in new window USTAV ORGANICKE CHEMIE A BIOCHEMIE, AKADEMIE VED CESKE REPUBLIKY Czechia EU contribution € 0,00 Address Flemingovo n. 2 Prague See on map Links Website Opens in new window COMBINATURE BIOPHARM AG Germany EU contribution € 0,00 Address Robert-rössle-str. 10 Berlin See on map Links Website Opens in new window MTA SZÁMÍTÁSTECHNIKAI ÉS AUTOMATIZÁLÁSI KUTATÓ INTÉZET (COMPUTER AND AUTOMATION RESEARCH INSTITUTE, HUNGARIAN ACADEMY OF SCIENCES) Hungary EU contribution € 0,00 Address Kende u. 13-17. Budapest See on map Links Website Opens in new window
