The 'Finding promising drug candidates against tuberculosis with multidisciplinary protocol based non-conventional search' (Scrin-silico) project's main objective was to develop a protocol that would help identify novel drug-binding sites and drug-protein complexes of Mycobacterium tuberculosis proteins. Team researchers aimed to develop a protocol with two main elements. The first involved a method for identifying surface indentation patterns in protein 3D structures. On the strength of data and information obtained from various experiments, high-throughput methods were used to perform pairwise searches to establish drug-protein binding. This was done in a rough first phase (Silico 1) and a more thorough investigative second phase (Silico 2). The second part of the project involved a structural and molecular biology protocol to guide examination of best-suited drug-protein pairs. This was done using various medium- and low-throughput methods. The Scrin-silico project succeeded in creating a widely applicable in silico/in vitro screening technology. This innovation opens the way for enhanced development of chemotherapies and can effectively address problems associated with multiple drug-resistance (MDR) and toxicity. The results of the project have increased European competitiveness in academic research and among biotech and pharmaceutical companies. Also, Scrin-silico has managed to establish a results-oriented link between European academia and industry. This will ultimately improve translation of scientific and research excellence into better processes and more beneficial health products.
Finding promising drug candidates against tuberculosis with multidisciplinary protocol based non-conventional search.
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29 March 2018