Objective
Multiple Sclerosis (MS) is a major pathology that is typically associated with central nervous system inflammations, demyelination and axonal loss. MS has a major economical impact on health care systems since it has currently no available cure. This pathology presents a clear sexual difference since women are representing over the two thirds of MS patients.
However the clinical outcome of women with MS is better than the one for men. It has been suggested that sexual steroid hormones play a role in this potential protection since women with remitting-relapsing form of MS undergo remission during the last trimester of pregnancy. This effect is more beneficial clinically than any effect induced by current pharmaceutical treatments. Studying remission induced by pregnancy is extremely relevant to understand the mechanisms involved in MS remission and for its potential to identify factors that may be developed as new therapeutic compounds.
The major goal of this project is to investigate through in vivo and gene array strategies, the cellular and molecular mechanisms underlying the protective effect of pregnancy in an experimentally induced murine model of MS. The first objective is to determine the specific parameters (i.e. inflammation, demyelination, or axonal loss) that are specifically modulated in vivo during pregnancy-induced remission. The second objective is to identify, through gene array analysis, factors that are specifically regulated during remission and that are involved in this mechanism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences clinical medicine obstetrics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
COLLERETTO GIACOSA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.