Some NEST have the potential to generate particulates which can enter the body via inhalation, ingestion or dermal absorption. As new materials are generated from sources as diverse as novel combustion systems, nanotechnology or pharmaceutical drug deliv ery in the life sciences there is potential for human exposure. Inhalation exposure to dusts leads to pulmonary diseases and particle toxicity increases with decreasing particle size. Information is needed regarding the possible risks from exposure to th ese particles including: the routes of exposure and subsequent disposition; their potential toxicity; appropriate toxicological testing procedures; and susceptible subpopulations. This study will acquire a bank of five particles potentially generated by N EST (NESTP) and will assess the health risk from exposure to these materials through air or the food supply with a work programme, integrating in vitro experiments, animal models of healthy/susceptible individuals and exposure/risk assessment.
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