Objective
The objective of this project is to co-finance a collaborative Workshop on "Systems biology of DNA damage induced stress responses" between researchers of the EU and the USA. The purpose of this Workshop is to develop better collaboration between researche rs in the EU and the US in a systems biology analysis of the principal pathways in the area of DNA-damage response. Heretofore, researchers focused on specific cellular compartments with regard to DNA-damage responses, such as cell cycle regulation, indu ction of apoptosis or DNA repair. However, work during the past few years has shown that there are strong interplays between specific steps in these major defence pathways and in order to fully understand cellular responses to DNA-damage, the cell must b e viewed as a large network of protein-protein and protein-DNA interactions that respond in a systematic way to DNA-damage. Researchers of the various DNA-damage response pathways have therefore recently embraced approaches in which global measurements of gene expression and the proteome can be combined with genome-wide screening of sensitivity mutants to develop an integrated view of how cells respond to and protect themselves against DNA damaging agents. The emerging picture from these global genomic studies is quite different from the previous concept of DNA repair, cell cycle control and induction of apoptosis as being independent processes. In fact these processes appear to form a fully integrated network. Integration of these genome-wide measure ments allows the development of specific models of response networks that could not have been detected or discerned previously. These models can be further refined and tested to improve mechanistic understanding. Specifically, the main goals of this Work shop are to enhance harmonization of protocols, to integrate databases and to increase communication between scientists in the EU and US in this field of research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences computer and information sciences internet
- natural sciences computer and information sciences databases
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences genetics mutation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-LIFESCIHEALTH-II
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.