Final Report Summary - BIOSYS (Intelligent Biomaterial Systems for Cardiovascular Tissue Repair)
Fibre production and optimisation were mainly carried out at Tampere University of Technology (TUT) at the Institute of Fibre Materials Science (TUT-FMS) and the Institute for Biomaterials (TUT-BIOM). TUT-FMS produced wet-spun and electro-spun fibres and TUT-BIOM produced melt-spun fibres from PLA. The medical, mechanical and structural properties provided the key requirements for the fibres produced by TUT-FMS and TUT-BIOM.
At TUT-BIOM the aim of the study was to produce as fine fibres as possible to be used in the textile and device manufacturing in this project. Fairly fine fibres were produced, characterised and analysed. Due to their greater strength and strength retention ability compared to the wet spun fibres they were used as constructive fibres for the cardiovascular graft.
At TUT-FMS, the study of wet-spun fibres started by solubility experiments of PLA. The solvents and coagulants were selected for the spinning experiments. Wet-spun fibres with different fibre properties were produced. Fibres were analysed and characterised. Fibre modification by adding bio molecule into the fibres has been studied as well. Electrospinning was used to coat moulded 3D heart valve implants made from non-woven mesh. Electrospun nanofibre structure contains interconnected pores, which are expected to initiate cell in-growth. Implants were sterilised with gamma irradiation.
At TUT-BIOM the aim of the study was to produce as fine fibres as possible to be used in the textile and device manufacturing in this project. Fairly fine fibres were produced, characterised and analysed. Due to their greater strength and strength retention ability compared to the wet spun fibres they were used as constructive fibres for the cardiovascular graft.
At TUT-FMS, the study of wet-spun fibres started by solubility experiments of PLA. The solvents and coagulants were selected for the spinning experiments. Wet-spun fibres with different fibre properties were produced. Fibres were analysed and characterised. Fibre modification by adding bio molecule into the fibres has been studied as well. Electrospinning was used to coat moulded 3D heart valve implants made from non-woven mesh. Electrospun nanofibre structure contains interconnected pores, which are expected to initiate cell in-growth. Implants were sterilised with gamma irradiation.
