Objective
Engineered tissues today in most cases lack appropriate connexion to the vascular system of the surrounding tissue in body at the implantation site. Hence the tissues suffer from malnutrition and low gas exchange leading to necrosis. To overcome this bottl eneck the strategic objective of this proposal is to develop a novel three-dimensional scaffold structure for improved vascularisation of tissue-engineered products. Application of intelligent biomaterials (bioresorbable stimuli-sensitive polymers) and inc orporation of bioactive substances (e.g. growth factors, monocyte-activating agents) will enhance a structured vascularisation of tissue-engineered constructs by gradually opening inserted microchannels for vessel ingrowth into cell-seeded polymeric scaffo lds. Furthermore, the mechanism of induction of secondary angiogenesis by monocytes will be used to control vascularisation. The signal for the stimulus-sensitive polymer to act (induction of angiogenesis) is intended to be a pH drop associated with malnut rition of cells.The use of angiogenic factors in promoting vascularisation of tissue-engineered constructs so far was performed by a rather isotropic distribution of factors in the scaffolds preventing the build-up of a gradient of bioactive substances for directed cell growth (angiogenesis). In our approach the tubular structure of the microchannels opened up upon activation of stimuli-sensitive filaments will guide cells involved in vascularisation and/or will provide a gradient for directed cell migratio n and growth. The composite scaffold giving rise to evolving vessels is intended to provide the vascular connexion to the surrounding tissue in the course of wound healing. The complex bunch of requirements for a functional vascularisation of tissue-engine ered products calls for a strong inter- and transdisciplinary cooperation of chemists, biologists, engineers, physicists and physicians depending on a pronounced cross-frontier collaboration.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences medical biotechnology tissue engineering
- natural sciences chemical sciences polymer sciences
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences medical biotechnology cells technologies
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NMP-TI-3-MAIN
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GEESTHACHT
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.