Objective
Cancer cells are induced to develop by pathological disfunction of signalling pathways. These are mediated by interactions between proteins in signalling cascades. As these processes are potentially specific for cancer cells, they offer the unprecedented opportunity to selectively intervene against tumour cells, without causing harm to normal cells. As signalling pathways are mediated by interactions between diverse signalling proteins, a straightforward possibility is to selectively inhibit specific signals is to block specific protein-protein interactions.
However, the contact areas between these proteins are often large, and most conventional drugs are too small to modulate these interactions effectively. Diverse chemical-, peptide- or whole-protein-based structures can be utilized as highly specific drugs. These are expected to modulate specific signalling pathways effectively, and to have much milder side effects on the patient. This approach is critically dependent on knowing the structures of the targeted proteins. However, in many cases the structures of the proteins concerned defy experimental determination, so we are critically dependent on prediction methods. These are not yet sufficiently accurate, so we are proposing to make a serious attempt a t improving them.
Three experienced researchers, with complementary expertise at protein structure prediction methods; bioinformatics, structure analysis and experimental validation will be employed. Interaction with wet-lab researchers and previous experience in multidisciplinary environments will critically help the exchange of knowledge, results and experimental approaches. Important results in key areas of both basic science and application to cancer therapy are expected from the implementation of these strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences cell biology
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences chemical sciences organic chemistry amines
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CHIETI SCALO (CHIETI)
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.