Objective
A multiplicity of inositol phosphates exists in biology, with functions in many diverse aspects of cell biology, such as ion channel physiology, membrane dynamics and nuclear signalling. This diversity involves a whole array of proteins that either metabolize inositol phosphates or mediate their intracellular functions.
Recently, a family of inositol phosphate kinases was identified whose members are conserved from yeast to humans. The main focus of the presented project is to study the inositol phosphate kinases, which are involved in the metabolism of the inositol pyrophosphates. Inositol pyrophosphates were recently shown to be a source of the high-energy phosphate for phosphorylation of certain proteins, similarly to ATP.
By solving the three dimensional structures of the recombinant inositol poly-phosphate kinases which make the inositol pyrophosphates, we would like to get a better insight into the metabolism of the inositol pyrophosphates and their biological roles. Besides X-ray crystallography as the main tool, other structural biology and biochemical techniques will be used to uncover still so many unknowns in this field of research.
The expected results are believed to represent a great contribution to the knowledge about the biologically very relevant molecules, inositol phosphates. Additionally, the opportunity for the applicant to professionally reintegrate in country of the nationality is also believed to be of a mutual benefit, for the scientist herself, her scientific career, and for the quality of the European research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
LJUBLJANA
Slovenia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.