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Control strategies for visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL) in South America: applications of molecular epidemiology.

Objective

A full and detailed understanding of the transmission cycles and epidemiology of visceral leishmaniasis (VL) and mucocutaneous leishmaniasis (MCL) is necessary to develop disease control and surveillance. Molecular epidemiology and population genetics can resolve the diversity and structure of Leishmania populations, for ex. the intricate relationships between clinical forms of human infection and mammal reservoirs. Research will involve comparative investigations between endemic areas for VL and MCL in Par aguay, Peru, Brazil and Venezuela and will strengthen local capacities for research and for Latin Am-European collaborations. The technical aim is to develop a full range of microsatellite markers and multi-locus sequencing typing (MLST) of housekeeping ge nes for the Leishmania braziliensis complex and for L guyanensis. We will also establish in South America the procedures for microsatellite and MLST analysis for L infantum, which have been developed and proven as epidemiological tools by a European networ k. The practical aims are to encourage the application of these and other molecular epidemiological methods in S. America for 1. elucidating parasite-vector-host relationships 2. assessing the epidemiological impact of VL-HIV co-infection (Brazil) 3. asses sing the epidemiological importance of recombinant Leishmania genotypes and 4. assessing the spread of resistance against 1st line treatment (SbV). In addition we will compare genotypes of a) Leishmania isolated from diverse clinical cases of leishmaniasis and b) drug susceptible and drug-resistant strains. The project will be undertaken in the context of an investigation of present understanding and intervention strategies among health professionals, defining how best to introduce project outputs into impr oved control. An accessible South American repository for Leishmania will be established, incorporating an existing collection, new isolates and representatives from other endemic regions.

Call for proposal

FP6-2003-INCO-DEV-2
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE
Address
Keppel Street
London
United Kingdom

Participants (11)

BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE
Germany
Address
Bernhard Nocht St 74
Hamburg
CENTRO DE CIENCIAS DA SAUDE DA UNIVERSIDADE FEDERAL DO PIAUÍ
Brazil
Address
Campus Petrônio Portela - Bloco 16 - Lib
Teresina - Piauí
CHARITE UNIVERSITAETSMEDIZIN BERLIN
Germany
Address
Schumannstr. 20/21
Berlin
FUNDAÇÃO OSWALDO CRUZ - INSTITUTO OSWALDO CRUZ
Brazil
Address
Avenida Presidente Vargas Brasil 590 Sala 1717
Rio De Janeiro
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD, UNIVERSIDAD NACIONAL DE ASUNCION
Paraguay
Address
Rio De La Plata Y Lagerenza
Asuncion
INSTITUTO DE SALUD CARLOS III
Spain
Address
Sinesio Delgado, 4
Madrid
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
Address
Nationalestraat, 155
Antwerpen
UNIVERSIDAD DE CARABOBO - CENTRO DE INVESTIGACIONES BIOMÉDICAS-CENTRO NACIONAL DE REFERENCIA DE FLEBOTOMOS DE VENEZUELA
Venezuela
Address
Callejón Cecilio Acosta, Urbanización Cantarrana, Sector La Rimconada, Las Delicias
Maracay
UNIVERSIDAD PERUANA CAYETANO HEREDIA/INSTITUTO DE MEDICINA TROPICAL "ALEXANDER VON HUMBOLDT"
Peru
Address
Av. Honorio Delgado 430, San Martin De Porres
Lima
UNIVERSIDADE FEDERAL DE MINAS GERAIS
Brazil
Address
Av. Antonio Carlos 6627
Belo Horizonte-mg
UNIVERSIDADE NOVA DE LISBOA/INSTITUTO DE HIGIENE E MEDICINA TROPICAL
Portugal
Address
Rua Da Junqueira, 96
Lisboa