Objective
The aim of this project is to develop a method for characterization of the structure and dynamics of polycrystals on length scales from the atomic-level to that of the sample. The method, TotalCryst, determines the atomic arrangement within each grain as w ell as the 3D position and morphology of the grains.
The structure of each grain can be solved and refined with accuracy presently obtainable only by studies of large single crystals. The method applies to inorganic structures as well as macromolecules and probes grains on all length scales from 100 nm to 1 mm. In this project it will be applied to studies within:Chemistry: TotalCryst will enable the identification and structural quantification of numerous complex or dilute structures which cannot be characterized by present methods. The method may find a widespread use in the pharmaceutical industry.
Firstly, it accelerates the process of structure determination, a bottleneck in the process of registration of a new drug. Secondly, it enables characterization of drug content, polymorphism and homogeneity in tablets. Structural biology: Attempting to solve ever-larger structures, crystal quality and radiation sensitivity are major concerns. TotalCryst is a novel strategy for overcoming these issues.
Time-resolved studies: TotalCryst offers a number of attractive and unique properties making it highly suitable for time-resolved studies. This includes conventional dynamic studies with time constants of the order of seconds as well as studies in the nano- to femt o-second regime based on stroboscopic methods involving a laser pump / X-ray probe scheme.
An example is the possibility to, for the first time, study photo-sensitive materials, e.g. photoactive switches for photovoltaic devices and pigments. The consortium comprises a group of crystallographers, X-ray physicists and computer scientists as well as experts in pharmacy, structural biology and time-resolved studies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- medical and health sciences basic medicine pharmacology and pharmacy
- natural sciences biological sciences molecular biology structural biology
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-NEST-B-3
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
KGS. LYNGBY
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.