Objective The overall objective of TAMIRUT is to develop an innovative bio-sensor concept devoted to advanced medical diagnosis, in which the biological material is carried by targeted micro-bubbles injected inside the body and the transducer is remote. The remote transducer operates on the basis of the ultrasound response of such micro-bubbles, gathered and processed by an improved version of an ultrasound medical scanner (UMS). Targeted micro-bubbles (similar to the generic micro-bubbles composing the contrast agents actually used in medical echography) are designed to bind only to a desired target region: a bio-conjugate ligand is attached to micro-bubble shells producing the adhesion of them to specific molecular signatures.The project goal is to exploit targeted micro-bubbles as bio-sensors producing measurements that will significantly complement the ultrasound molecular imaging and improve the medical diagnosis potential. Among many potential medical applications, the case study that will be addressed in the TAMIRUT project concerns the early detection, the assessment of the micro-vessel density, and the correct staging and grading of the prostate cancer. Such tasks will be dramatically improved by developing appropriate targeted micro-bubbles (i.e. bubbles able to bind on the endothelium of the neo-vessels of such a cancer) and measuring their local concentrations by means of the novel bio-sensor.In addition, the repetition over time of such a measurement could help in assessing the disease evolution, especially regarding the angiogenesis aspects. The main objective of this project will be pursued by a multidisciplinary, strictly joint development of all the bio-sensor components, taking into account the need to remotely interrogate targeted micro-bubbles. In turn, micro-bubbles and bioconjugate ligands will be refined and tuned taking into account the desires of the medical community in relation to the introduction of new bio-sensor and addressed case study. Fields of science medical and health sciencesclinical medicineoncologyprostate cancerengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsengineering and technologyenvironmental biotechnologybiosensingengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsignal processingnatural sciencesphysical sciencesacousticsultrasound Keywords Nanotechnology Programme(s) FP6-NMP - Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new production processes and devices: thematic priority 3 under the 'Focusing and integrating community research' of the 'Integrating and strengthening the European Research Area' specific programme 2002-2006. Topic(s) NMP-2004-IST-NMP-2 - Bio-sensors for Diagnosis and Healthcare Call for proposal FP6-2004-IST-NMP-2 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator .ESAOTE SPA EU contribution No data Address Viale Bianca Maria 25 MILANO Italy See on map Links Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITEIT TWENTE Netherlands EU contribution No data Address Drienerlolaan 1 ENSCHEDE See on map Links Website Opens in new window Total cost No data BRACCO RESEARCH SA Switzerland EU contribution No data Address Route de la Galaise, 31 PLAN-LES-OUATES See on map Total cost No data UNIVERSITA DEGLI STUDI DI GENOVA Italy EU contribution No data Address Via Balbi 5 GENOVA See on map Links Website Opens in new window Total cost No data VERMON SA France EU contribution No data Address Rue du General Renault 180 TOURS See on map Links Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAET INNSBRUCK Austria EU contribution No data Address Christoph-Probst Platz 1 INNSBRUCK See on map Links Website Opens in new window Total cost No data SIGNALGENERIX LTD Cyprus EU contribution No data Address Maximos Court, Block B, 3rd Floor, Leontiou A LIMASSOL See on map Links Website Opens in new window Total cost No data ERASMUS MEDICAL CENTER ROTTERDAM Netherlands EU contribution No data Address Dr. Molewaterplein 50 ROTTERDAM See on map Links Website Opens in new window Total cost No data ESAOTE SPA Italy EU contribution No data Address Via Camperio 9 MILANO See on map Links Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. Germany EU contribution No data Address Hansastrasse 27 C MUNCHEN See on map Links Website Opens in new window Total cost No data