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Investigation of metabolic processes underlying brain myelination defects using magnetic resonance spectroscopy of oligodendrocyte extracts

Objetivo

Genetic factors are responsible for many degenerative diseases of the nervous system. Proteolipid protein (PLP), the most abundant myelin protein of the central nervous system (CNS), is positioned in compact myelin, and alterations in the processing of PLP are a major cause in inherited diseases of CNS myelin. For instance, the Pelizaeus Merzbacher disease is a disorder of the central nervous myelination, caused in most cases by mutations involving the PLP gene.

It has been known for several years that myelin formation in the mammalian CNS is closely related to the oligodendrocyte population, and that the latter may be regulated by apoptosis. It is also known that PLP mutations resulting in demyelination lead to extended oligodendrocyte apoptosis. The proposed research aim is to investigate metabolic processes underlying myelination defects in the CNS.

Ámbito científico (EuroSciVoc)

Palabras clave

Tema(s)

Convocatoria de propuestas

FP6-2002-MOBILITY-12
Consulte otros proyectos de esta convocatoria

Régimen de financiación

IRG - Marie Curie actions-International re-integration grants

Coordinador

UNIVERSITE LOUIS PASTEUR
Aportación de la UE
Sin datos
Dirección


Francia
Coste total
Sin datos