Objective
Correct chromosome segregation is an essential process in the mitotic cell division. This still poorly understood process occurs during mitosis and has recently been associated with cancer. The mitotic spindle is a complex structure regulated at multiple levels including the control of its formation by phosphorylation. Among the mitotic kinases, the Aurora family of proteins have specific roles in this process. Aurora A is a mitotic kinase commonly deregulated in human cancer and whose over-expression has been shown to induce mitotic defects, aneuploidy, and oncogenic transformation in vitro. However, the exact function of this protein is not well understood and we still do not know many of its substrates.
In this project, we will develop a mouse model of Aurora-A inactivation by generating a conditional knock out for the Aurora-A (Stk6) gene. In addition, to investigate its role on tumour development and progression, we well generate a knock in mouse that will express a non-degradable form of this protein, and therefore resistant to its proteolytic degradation in mitosis. Both mouse models, for loss-of-function and gain-of-function, of Aurora-A will provide essential reagents to understand not only the biology of mammalian Aurora-A in vivo, but also for a better knowledge of the role in cancer of this protein, one of the few mitotic regulators that have been associated with tumour progression. Finally, this mouse model with altered mitotic regulation will be a valuable tool to improve current therapeutic strategies in cancer, mostly directed against mitotic progression.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.