Objective
The goal of this CRAFT consortium is the generation of a prototype of a new generation of drugs, which are based on the combination of established technologies in the field of protein engineering, DNA-targeting and drug delivery. The combination of the diverse fields of technology is very innovative and a reachable task. As prototype we aim for a double targeted therapeutic compound which is a carcinoma cell specific delivered and carcinoma gene specific in his DNA-methyltransferase activity which can switch the expression of a tumour-associated gene involved in carcinogenesis expressed in 40% of all human tumours, from on to off. Cancer is the second cause of death in the Western world and continues to emerge at an accelerated rate in the developing countries as well. Although progress has been made in the therapy of some types of cancer, the overall survival prognosis with current standard therapy is poor. Therefore, new treatment strategies are needed. The approach we propose here is based on the selective silencing of the epithelial glycoprotein-2 (EGP-2) gene, which is abundantly expressed in a variety of carcinomas, counting for 40% of all cancers. The goal of the proposed method is to selectively silence the EGP-2 gene by targeted methylation of the EGP-2 promoter. The therapeutic compounds we wish to develop consist of a targeted DNA methyltransferase and a targeted delivery system, based on synthetic amphiphiles, specific for EGP-2 positive cells. The targeted DNA-methyltransferase is a covalent complex of a triplex forming oligonucleotide (TFO) and the CpG-specific DNA methyltransferase M.SssI. This TFO-M.SssI conjugate has the potential to methylate a unique CpG site in a genome. Because of the high targeting specificity of the envisaged product, the proposed approach is expected to be free of many negative side effects, and thus can lead to a more effective treatment of a broad-range of cancers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2003-SME-1
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Coordinator
GRONINGEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.