Objective
The overall objective of THOVLEN is to develop safe and efficient herpes simplex virus type 1 (HSV-1)-derived oncolytic vectors, designed to strictly target and eradicate human hepatocellular carcinomas (HCC), the most common liver cancer of adults. HSV-1 is certainly one of the most promising viral platforms for the development of improved oncolytic vectors, as anticipated by the unique biological properties of this virus and confirmed by the encouraging results coming from clinical trials in gliomas. However, the first generations of oncolytic HSV-1 vectors have also shown limitations regarding efficacy and safety. New generations of innovative HSV-1 vectors with improved potency and safety are required before the oncolytic strategy using HSV-1 becom es a standard therapeutic reality against cancer, and this is the goal of THOVLEN. One of the most important innovative contributions of our project concerns the overall approach towards the improvement of HSV-1-based oncolytic viruses. Instead of focusi ng on the development of vectors carrying deletions in particular virus genes, we will engineer competent, but replication-restricted, HSV-1 vectors, strictly targeted to HCC. These vectors will combine multiple HCC-targeting approaches, both at the leve l of entry and at the level of gene expression and replication, and will be able to multiply and spread only in HCC, while displaying no virulence in normal healthy tissues. Additionally, an important innovation is related to the ability of the HSV-1 vec tors to permit a sophisticated and flexible combined approach against HCC. That is, in addition to optimizing the oncolytic properties of HSV-1 vectors, THOVLEN will exploit the very large transgenic capability of HSV-1 to generate vectors that will sim ultaneously display multiple and multimodal anti-tumour activities acting either locally or systemically, including combined expression of anti-angiogenic, immune-modulatory, and oncolytic pr
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology liver cancer
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases DNA viruses
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VILLEURBANNE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.