Objective
Nuclear receptors function throughout development and aging as molecular integrators of complex physiological regulations, such as growth, reproduction and metabolism. To translate genetic knowledge from the Human Genome into therapy requires intimate understanding of fundamental regulatory mechanisms. CRESCENDO will build on existing knowledge and infrastructures by drawing together European excellence to focus on signalling dynamics, integration of target gene responses during development and aging, and human genetics and pathophysiology, emphasising key nuclear receptors. State-of-the-art genomic and post-genomic techniques will lever advances on mechanisms and kinetics of nuclear receptor signalling in processes underlying development and aging. Information on spatial and temporal aspects of signalling dynamics will feed into a broader vision of how nuclear receptors integrate multiple inputs in whole organisms across the life span. Focus will be on developmental targets, on brain development and aging, and the complex interplay between metabolism, particularly glucose and lipid signalling, and brain function. The brain is emphasised, as its disorders often cause most distress in unhealthy aging. A strong investment in bioinformatics will facilitate data extraction from multi-level analyses (genes to cells to organisms) and accelerate determination of targets, regulatory networks and integration of physiological responses within individuals and populations. The consortium includes molecular and developmental biologists, physiologists and human geneticists, and has access to major national and transnational data banks and resources. Nuclear receptor research is being revolutionised by the combination of technological advances with novel insights into signalling processes. CRESCENDO will ensure that European research in the field accelerates its momentum, fulfilling its potential to catalyse therapeutic innovation and to create substantial socio-economic benefit.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences basic medicine medical genetics
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
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Participants (20)
STOCKHOLM
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HELSINGIN YLIOPISTO, HELSINKI
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HEIDELBERG
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MUNICH
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MILAN
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GENEVA 4
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MADRID
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PRAGUE 4
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1046 Blindern OSLO
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NEUHERBERG
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NAPOLI
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HEIDELBERG
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10142 ILLKIRCH
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PARIS
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SURESNES
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Novum HUDDINGE
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CASERTA
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SINGAPORE
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LAUSANNE
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HUDDINGE
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