Objective
The circadian clock is a basic biological process that enables organisms to anticipate daily environmental changes by adjusting behavior, physiology and gene regulation. It impacts health and quality of life in regulating sleep and well-being, in the consequences of shift-work, in medical diagnosis/therapy, and in age-related changes.
A critical feature of the clock is its synchronization to the external day (entrainment). Entrainment is the key to understanding the circadian clock and its control mechanisms. In EUCLOCK, highly competitive European researchers join forces to investigate the circadian clock under entrainment using the most advanced methods of functional genomics and phenomics comparing powerful genetic model organisms (humans, mice, flies, and yeast).
Its four major innovations will shape the future of circadian research:
- To compare genomic and phenomic aspects of the clock, SOPs will be developed for the first time that mimic aspects of the natural day (dawn/dusk, day-lengths, etc).
- Protocols, devices and algorithms will be developed, enabling for the first time large-scale, non-invasive research on human entrainment in the field.
- Developing the first animal models for shift-work, making animals 'work' and feed out of phase with their natural rhythms. The ensuing "dys-entrainment" will be investigated at all levels, aiming to provide the insights needed to treat the symptoms and consequences of human shift-work.
- Building on genome sequences, new genetic components and interactions will be identified that control the circadian clock and its entrainment.
For the first time the experimental advantages of yeast will be extensively used. The tractability of yeast permits integration and reconstruction of elements and interactions gleaned from other systems. Together, these approaches allow systems biology research on circadian timing to be performed and integrated at the level of the genome, the proteome, and the metabolome.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine physiology
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MUNICH
Germany
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Participants (28)
FRIBOURG
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GRONINGEN
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REGENSBURG
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OXFORD
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BERLIN
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LEICESTER
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9503 LEIDEN
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MÜNCHEN-NEUHERBERG
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TARTU
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EDINBURGH
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521 SZEGED
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LONDON
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GIF-SUR-YVETTE
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GUILDFORD
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PRAGUE
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1738 ROTTERDAM
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BASEL
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NOVOSIBIRSK
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EDINBURGH
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BONSTETTEN
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ZURICH
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90174 AMSTERDAM
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LAUSANNE
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SCHÖNENBUCH
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LONDON
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PARIS
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PADOVA
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GENEVE 4
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