Objective
Linkage studies of cancer families have identified high-penetrance cancer genes such as BRCA1 and BRCA2. However, although these genes have resulted in novel insights into cancer, it is clear that a large component of inherited cancer risk remains unacc ounted for. It has been proposed that common low penetrance cancer susceptibility genes contribute significantly to the genetic predisposition of cancer in a polygenic model of inheritance. Association studies have been suggested as the method of choic e for finding susceptibility alleles of high frequency but low penetrance. Here, we propose to take advantage of accumulating genomic data and two European populations of different history and structure to determine the contribution of candidate cancer susceptibility genes to different clinical forms of breast and prostate cancer. We will use a population based association study in Iceland and the Netherlands to map the risk profiles associated with common polymorphic variants in and near candidate c ancer susceptibility genes in breast and prostate cancer patients. We will also develop methods for statistical analysis of complex genomic data which can be used in this and other projects. The proposed study has the potential to cast light on how gen etic variants affect the risk of cancer initiation and how it affects progression and response to treatment. Finally, the results may serve as a starting point for building models of genetic risk of these cancers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology prostate cancer
- medical and health sciences health sciences public health
- humanities history and archaeology history
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences computer and information sciences computational science
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
REYKJAVIK
Iceland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.