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Genomics of Cardiomyocyte Signalling to Treat and Prevent Heart Failure

Objective

EUGeneHeart will develop new approaches to prevent and treat heart failure through analysis of the genomics of signalling. Our strategy is based on the hypothesis that beneficial and maladaptive forms of hypertrophy exist and that heart failure is frequently preceded by maladaptive hypertrophy. We will dissect both adaptive and maladaptive signalling in hypertrophy to identify beneficial and maladaptive components of signal transduction in hypertrophy and heart failure. The EUGeneHeart consortium forms an extremely integrated project comprised of six major tasks. In Task 1, murine models will be analysed (phenotyped) in an integrated matrix approach: Wildtype mice will be subjected to pressure overload, myocardial infarction, and chronic exercise, genetically modified mice with a beneficial response to these stressors will be compared for differences in signal transduction. Task 2 identifies new players in different forms of hypertrophy and failure using screening techniques including proteomics and microarrays, forward and reverse genetics in drosophila and zebrafish, validation in murine models and patient cohorts. Task 3 exploits knowledge generated in the first two tasks and translates knowledge on existing pharmacological interventions to generate new candidate drugs in close involvement of SME's. Candidate small molecules and molecule libraries will be tested in a successive developmental platform. This will lead to patent filing, licensing strategies and to phase I and II clinical trials. Task 4 contains specific questions related to sex differences and to signalling in hypertrophy. Our approach takes account of national research activities and recruits knowledge, patients and tissues at a European level.Task 5 includes a training initiative and Task 6 contains the Management activities of the project. The ultimate accomplishment will include improvement of health, reduction of health expenses,creation of new jobs and economic benefit.

Field of science

  • /natural sciences/biological sciences/genetics and heredity

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS
Address
Robert-koch-str. 40
Goettingen
Germany

Participants (21)

UNIVERSITÉ CATHOLIQUE DE LOUVAIN
Belgium
Address
Place De L'université, 1
Louvain-la-neuve
FONDAZIONE PARCO BIOMEDICO SAN RAFFAELE
Italy
Address
Via Castel Romano 100
Rome
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN
Netherlands
Address
Uppsalalaan 8
Utrecht
UNIVERSITY MEDICAL CENTER UTRECHT
Netherlands
Address
Heidelberglaan 100
85500 Utrecht
UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF
Germany
Address
Martinistraße 52
Hamburg
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris
UNIVERSITY OF SZEGED
Hungary
Address
Dugonics Tér 13
Szeged
CHARITE UNIVERSITÄTSMEDIZIN BERLIN
Germany
Address
Schumannstr. 2-21
Berlin
KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven
UNIVERSITA' DEGLI STUDI DI TORINO
Italy
Address
Via Verdi 8
Torino
UNIVERSITEIT MAASTRICHT
Netherlands
Address
Universiteitssingel 50 - 6229 Er
616 Maastricht
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm
THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford
ÚSTAV MOLEKULÁRNEJ FYZIOLÓGIE A GENETIKY SLOVENSKEJ AKADÉMIE VIED
Slovakia
Address
Vlárska 5
Bratislava
NUCLEIS SA
France
Address
60 Avenue Rockfeller
Lyon
GREENPHARMA S.A.
France
Address
3, Allée Du Titane
Orléans
APEIRON BIOLOGICS FORSCHUNGS UND ENTWICKLUNGS GMBH
Austria
Address
Brunner Strasse 59
Vienna
INSTITUTE OF MOLECULAR BIOTECHNOLOGY OF THE AUSTRIAN ACADEMY OF SCIENCES
Austria
Address
Dr. Bohrgasse 3-5
Vienna
GENOWAY SA
France
Address
181 Avenue Jean Jaurès
Lyon
ENDOTHERM GMBH
Germany
Address
Science Park 2
Saarbrücken