Genomics of Cardiomyocyte Signalling to Treat and Prevent Heart Failure

Objective

EUGeneHeart will develop new approaches to prevent and treat heart failure through analysis of the genomics of signalling. Our strategy is based on the hypothesis that beneficial and maladaptive forms of hypertrophy exist and that heart failure is frequently preceded by maladaptive hypertrophy. We will dissect both adaptive and maladaptive signalling in hypertrophy to identify beneficial and maladaptive components of signal transduction in hypertrophy and heart failure. The EUGeneHeart consortium forms an extremely integrated project comprised of six major tasks. In Task 1, murine models will be analysed (phenotyped) in an integrated matrix approach: Wildtype mice will be subjected to pressure overload, myocardial infarction, and chronic exercise, genetically modified mice with a beneficial response to these stressors will be compared for differences in signal transduction. Task 2 identifies new players in different forms of hypertrophy and failure using screening techniques including proteomics and microarrays, forward and reverse genetics in drosophila and zebrafish, validation in murine models and patient cohorts. Task 3 exploits knowledge generated in the first two tasks and translates knowledge on existing pharmacological interventions to generate new candidate drugs in close involvement of SME's. Candidate small molecules and molecule libraries will be tested in a successive developmental platform. This will lead to patent filing, licensing strategies and to phase I and II clinical trials. Task 4 contains specific questions related to sex differences and to signalling in hypertrophy. Our approach takes account of national research activities and recruits knowledge, patients and tissues at a European level.Task 5 includes a training initiative and Task 6 contains the Management activities of the project. The ultimate accomplishment will include improvement of health, reduction of health expenses,creation of new jobs and economic benefit.

Field of science

• /natural sciences/biological sciences/genetics and heredity

Programme(s)

• FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006.

Topic(s)

• LSH-2004-2.1.1-1 - Genomics of cardiomyocyte signalling relevant to heart failure

Call for proposal

FP6-2004-LIFESCIHEALTH-5
See other projects for this call

Funding Scheme

IP - Integrated Project

Coordinator

UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS

Address

Robert-koch-str. 40
Goettingen
Germany

Participants (21)

UNIVERSITÉ CATHOLIQUE DE LOUVAIN

Belgium

Address

Place De L'université, 1
Louvain-la-neuve

FONDAZIONE PARCO BIOMEDICO SAN RAFFAELE

Italy

Address

Via Castel Romano 100
Rome

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN

Netherlands

Address

Uppsalalaan 8
Utrecht

UNIVERSITY MEDICAL CENTER UTRECHT

Netherlands

Address

Heidelberglaan 100
85500 Utrecht

UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF

Germany

Address

Martinistraße 52
Hamburg

INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

France

Address

101 Rue De Tolbiac
Paris

UNIVERSITY OF SZEGED

Hungary

Address

Dugonics Tér 13
Szeged

CHARITE UNIVERSITÄTSMEDIZIN BERLIN

Germany

Address

Schumannstr. 2-21
Berlin

KING'S COLLEGE LONDON

United Kingdom

Address

Strand
London

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

Address

Oude Markt 13
Leuven

UNIVERSITA' DEGLI STUDI DI TORINO

Italy

Address

Via Verdi 8
Torino

UNIVERSITEIT MAASTRICHT

Netherlands

Address

Universiteitssingel 50 - 6229 Er
616 Maastricht

KAROLINSKA INSTITUTET

Sweden

Address

Nobels Väg 5
Stockholm

THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

Address

University Offices, Wellington Square
Oxford

ÚSTAV MOLEKULÁRNEJ FYZIOLÓGIE A GENETIKY SLOVENSKEJ AKADÉMIE VIED

Slovakia

Address

Vlárska 5
Bratislava

NUCLEIS SA

France

Address

60 Avenue Rockfeller
Lyon

GREENPHARMA S.A.

France

Address

3, Allée Du Titane
Orléans

APEIRON BIOLOGICS FORSCHUNGS UND ENTWICKLUNGS GMBH

Austria

Address

Brunner Strasse 59
Vienna

INSTITUTE OF MOLECULAR BIOTECHNOLOGY OF THE AUSTRIAN ACADEMY OF SCIENCES

Austria

Address

Dr. Bohrgasse 3-5
Vienna

GENOWAY SA

France

Address

181 Avenue Jean Jaurès
Lyon

ENDOTHERM GMBH

Germany

Address

Science Park 2
Saarbrücken