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Genomics of Cardiomyocyte Signalling to Treat and Prevent Heart Failure

Objective

EUGeneHeart will develop new approaches to prevent and treat heart failure through analysis of the genomics of signalling. Our strategy is based on the hypothesis that beneficial and maladaptive forms of hypertrophy exist and that heart failure is frequently preceded by maladaptive hypertrophy. We will dissect both adaptive and maladaptive signalling in hypertrophy to identify beneficial and maladaptive components of signal transduction in hypertrophy and heart failure. The EUGeneHeart consortium forms an extremely integrated project comprised of six major tasks. In Task 1, murine models will be analysed (phenotyped) in an integrated matrix approach: Wildtype mice will be subjected to pressure overload, myocardial infarction, and chronic exercise, genetically modified mice with a beneficial response to these stressors will be compared for differences in signal transduction. Task 2 identifies new players in different forms of hypertrophy and failure using screening techniques including proteomics and microarrays, forward and reverse genetics in drosophila and zebrafish, validation in murine models and patient cohorts. Task 3 exploits knowledge generated in the first two tasks and translates knowledge on existing pharmacological interventions to generate new candidate drugs in close involvement of SME's. Candidate small molecules and molecule libraries will be tested in a successive developmental platform. This will lead to patent filing, licensing strategies and to phase I and II clinical trials. Task 4 contains specific questions related to sex differences and to signalling in hypertrophy. Our approach takes account of national research activities and recruits knowledge, patients and tissues at a European level.Task 5 includes a training initiative and Task 6 contains the Management activities of the project. The ultimate accomplishment will include improvement of health, reduction of health expenses,creation of new jobs and economic benefit.

Call for proposal

FP6-2004-LIFESCIHEALTH-5
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Coordinator

UNIVERSITÄTSMEDIZIN GÖTTINGEN - GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN - STIFTUNG ÖFFENTLICHEN RECHTS
Address
Robert-koch-str. 40
Goettingen
Germany

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Participants (21)

UNIVERSITÉ CATHOLIQUE DE LOUVAIN
Belgium
Address
Place De L'université, 1
Louvain-la-neuve

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FONDAZIONE PARCO BIOMEDICO SAN RAFFAELE
Italy
Address
Via Castel Romano 100
Rome

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KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN
Netherlands
Address
Uppsalalaan 8
Utrecht

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UNIVERSITY MEDICAL CENTER UTRECHT
Netherlands
Address
Heidelberglaan 100
85500 Utrecht

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UNIVERSITY MEDICAL CENTER HAMBURG-EPPENDORF
Germany
Address
Martinistraße 52
Hamburg

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INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
France
Address
101 Rue De Tolbiac
Paris

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UNIVERSITY OF SZEGED
Hungary
Address
Dugonics Tér 13
Szeged

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CHARITE UNIVERSITÄTSMEDIZIN BERLIN
Germany
Address
Schumannstr. 2-21
Berlin

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KING'S COLLEGE LONDON
United Kingdom
Address
Strand
London

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KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Address
Oude Markt 13
Leuven

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UNIVERSITA' DEGLI STUDI DI TORINO
Italy
Address
Via Verdi 8
Torino

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UNIVERSITEIT MAASTRICHT
Netherlands
Address
Universiteitssingel 50 - 6229 Er
616 Maastricht

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KAROLINSKA INSTITUTET
Sweden
Address
Nobels Väg 5
Stockholm

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THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Address
University Offices, Wellington Square
Oxford

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ÚSTAV MOLEKULÁRNEJ FYZIOLÓGIE A GENETIKY SLOVENSKEJ AKADÉMIE VIED
Slovakia
Address
Vlárska 5
Bratislava

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NUCLEIS SA
France
Address
60 Avenue Rockfeller
Lyon

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GREENPHARMA S.A.
France
Address
3, Allée Du Titane
Orléans

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APEIRON BIOLOGICS FORSCHUNGS UND ENTWICKLUNGS GMBH
Austria
Address
Brunner Strasse 59
Vienna

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INSTITUTE OF MOLECULAR BIOTECHNOLOGY OF THE AUSTRIAN ACADEMY OF SCIENCES
Austria
Address
Dr. Bohrgasse 3-5
Vienna

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GENOWAY SA
France
Address
181 Avenue Jean Jaurès
Lyon

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ENDOTHERM GMBH
Germany
Address
Science Park 2
Saarbrücken

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