Objective
EUGeneHeart will develop new approaches to prevent and treat heart failure through analysis of the genomics of signalling. Our strategy is based on the hypothesis that beneficial and maladaptive forms of hypertrophy exist and that heart failure is frequently preceded by maladaptive hypertrophy. We will dissect both adaptive and maladaptive signalling in hypertrophy to identify beneficial and maladaptive components of signal transduction in hypertrophy and heart failure. The EUGeneHeart consortium forms an extremely integrated project comprised of six major tasks. In Task 1, murine models will be analysed (phenotyped) in an integrated matrix approach: Wildtype mice will be subjected to pressure overload, myocardial infarction, and chronic exercise, genetically modified mice with a beneficial response to these stressors will be compared for differences in signal transduction. Task 2 identifies new players in different forms of hypertrophy and failure using screening techniques including proteomics and microarrays, forward and reverse genetics in drosophila and zebrafish, validation in murine models and patient cohorts. Task 3 exploits knowledge generated in the first two tasks and translates knowledge on existing pharmacological interventions to generate new candidate drugs in close involvement of SME's. Candidate small molecules and molecule libraries will be tested in a successive developmental platform. This will lead to patent filing, licensing strategies and to phase I and II clinical trials. Task 4 contains specific questions related to sex differences and to signalling in hypertrophy. Our approach takes account of national research activities and recruits knowledge, patients and tissues at a European level.Task 5 includes a training initiative and Task 6 contains the Management activities of the project. The ultimate accomplishment will include improvement of health, reduction of health expenses,creation of new jobs and economic benefit.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesgenetics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesclinical medicinecardiology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback.
You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Call for proposal
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
IP - Integrated ProjectCoordinator
GOETTINGEN
Germany
See on map
Participants (21)
LOUVAIN-LA-NEUVE
See on map
ROME
See on map
UTRECHT
See on map
85500 UTRECHT
See on map
HAMBURG
See on map
PARIS
See on map
SZEGED
See on map
BERLIN
See on map
LONDON
See on map
LEUVEN
See on map
TORINO
See on map
616 MAASTRICHT
See on map
STOCKHOLM
See on map
OXFORD
See on map
BRATISLAVA
See on map
LYON
See on map
ORLÉANS
See on map
VIENNA
See on map
VIENNA
See on map
LYON
See on map
SAARBRÜCKEN
See on map