Objective
The field of gene therapy has matured and the prospects are exciting and hopeful since some treatments have now been shown to be effective in the clinic. However, precise quality and safety standards for clinical gene transfer have yet to be defined. Defining optimal methods for the production of standard vector systems would pave the way for accelerated development and improved safety. This would be of enormous value to industry, individual investigators and regulators.
The NoE goal is the creation of a European Network for the Advancement of Clinical Gene Transfer and Therapy (CLINIGENE) integrating multidisciplinary research & development in gene therapy and mobilising all major stakeholders involved in the development of gene therapy medicinal products: academia, industry, regulatory bodies, clinics and patients. CLINIGENE will generate platform databases for particular vectors with respect to their safety and efficacy to ensure product manufacturing according to well-defined quality and safety standards in order to accelerate clinical trials. This will be achieved by compiling all available information and then ranking test and control methods by comparison and through validation by expert partners. The JPA comprises
1. Integration activites: sharing facilities, exchange and high-level training of personnel, e-communication, collaboration with the ESGT
2. Research activities: 6 horizontal activities serving integration towards the generation of reference/standard profile data-bases - AAV, gamma-retrovirus, lentivirus, adenovirus, genetically-modified cells & non-viral vectors - & 4 vertical activities defining a path to optimised clinical protocols - quality and efficacy (manufacture), safety (pharm-tox and virus safety); pre-clinical models and novel assessment tools, clinical trials
3. Dissemination activities: training, high-level education, communication (including a web-site with scientific & medical data-bases), management of shared information, IPR.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences databases
- medical and health sciences medical biotechnology genetic engineering gene therapy
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences biological sciences microbiology virology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CACHAN
France
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Participants (42)
LONDON
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ROME
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HANNOVER
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BELLATERRA (CERDANYOLA DEL VALLES)
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PRAGUE 4
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LANGEN
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OEIRAS
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STOCKHOLM
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MÜNCHEN
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BRAUNSCHWEIG
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HEIDELBERG
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ULM
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BP60 EVRY
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PARIS
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NANTES
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JERUSALEM
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MILANO
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ROCHESTER
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1627 KUOPIO
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INNSBRUCK
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PARIS
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STIRLING
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FREIBURG
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BOUFFERE
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PARIS
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EVRY
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OXFORD
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BIELEFELD
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12247 JERUSALEM
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CACHAN
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TRIESTE
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74 02 38 BERLIN
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BRUSSEL
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AMADORA
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CASE 922 MARSEILLE
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PARIS
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PARIS
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PARIS
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TW20 0EX Egham
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STRASBOURG
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LAUSANNE
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KOELN
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