Objective
Ageing is accompanied by several "age-associated' diseases, most of them involving tissue disorganization associated with a loss of tissue elasticity, with multiple physiological, mechanical and social consequences.
The goal of this proposal is to target the ageing of elastic tissue to cope with ageing, or at least some manifestations of ageing. As the mechanisms that govern correct elastogenesis during development, which are lost in adulthood and ageing, are still unknown, and as it is also unknown how to reactivate these processes, the project introduces a coordinated action to find "positive modulators" (protection against degradation and post-translational modification, re-induction of optimal elastogenesis) of elastic tissue ageing.
The originality of the proposal lies in the Coordination of strategies that will define:
- Rodent and tissue-equivalent models to study the impact of therapeutic approaches on elastic tissue ageing
- The development of diverse elastic fibre-derived peptides - proteoglycan conjugates based on the elastic fibre components structure and its alterations with age, in order to protect or delay elastic fibre degradation or post-translational modification
- The development of strategies to assess neosynthesis of elastic tissues and to define biomarkers at the cross-roads between ageing and elastic tissue ageing.
Assays on cells from humans displaying genetically-based "exaggerated" ageing will be used as indicators of the effectiveness of the selected "modulators". The expected impacts should be a breakthrough on skin and vessel ageing treatments with a special interest with the improvement of chronic vein insufficiency and, longer term, other disorders of joints, arteries and macula and the improvement of healing.
The project brings together 12 participants with complementary expertise from 6 different countries, including basic scientists, clinicians and three SMEs. Ethical, gender and standardisation aspects are also included.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine ophthalmology glaucoma
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences medical biotechnology tissue engineering
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
VILLEURBANNE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.