ELEM Virtual Heart Populations for Supercomputers

Project Information

ELVIS

Grant agreement ID: 190134524

DOI

10.3030/190134524

Project closed

EC signature date 11 April 2023

Start date 1 March 2023

End date 31 August 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 3 545 852,50

EU contribution

€ 2 482 096,75

Coordinated by

ELEM BIOTECH SL
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

A collection of papers published or on the process to be published on clinical validation.

Publications

Monographic books (2)

Impact of endocrine disruptors from mother's diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool

Author(s): A Fucic1 , A Mantovani, J Vena, M S Bloom , N Sincic , M Vazquez , J Aguado-Sierra
Published in: Reproductive Toxicology, 2023
Publisher: ELSEVIER
DOI: 10.1016/j.reprotox.2023.108357

"HPC Framework for Performing in Silico Trials Using a 3D Virtual Human Cardiac Population as Means to Assess Drug-Induced Arrhythmic Risk."" High Performance Computing for Drug Discovery and Biomedicine"

Author(s): Jazmin Aguado-Sierra , Renee Brigham, Apollo K Baron , Paula Dominguez Gomez , Guillaume Houzeaux, Jose M Guerra , Francesc Carreras, David Filgueiras-Rama, Mariano Vazquez, Paul A Iaizzo, Tinen L Iles, Constantine Butakoff
Published in: High Performance Computing for Drug Discovery and Biomedicine
Publisher: Humana, New York, NY
DOI: 10.1007/978-1-0716-3449-3_14

Conference proceedings (1)

A 3D Electromechanical Model of the Human Atria: A Realistic Framework for the Study of Atrial Fibrillation

Author(s): Eva Casoni; Constantine Butakoff; Jazmin Aguado-Sierra; Violeta Puche; Beatriz Trenor; Javier Saiz; Mariano Vazquez
Published in: IEEE Xplore, 2023
Publisher: IEEE
DOI: 10.22489/CINC.2023.200

Peer reviewed articles (6)

Digital twins and Big AI: the future of truly individualised healthcare

Author(s): Peter Coveney, Roger Highfield, Eric Stahlberg, Mariano Vázquez
Published in: npj Digital Medicine, Issue 8, 2025, ISSN 2398-6352
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41746-025-01874-X

A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc

Author(s): Dimitrios Lialios, Beatriz Eguzkitza, Guillaume Houzeaux, Eva Casoni, Laura Baumgartner, Jérôme Noailly, Estefano Muñoz-Moya, Benjamin Gantenbein, Mariano Vázquez
Published in: Computer Methods and Programs in Biomedicine, Issue 259, 2024, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/J.CMPB.2024.108493

Replicating clinical placebo effects in computational trials: Bridging the gap between in silico and clinical studies

Author(s): Paula Dominguez-Gomez, Constantine Butakoff, Georg Rast, Borje Darpo, Mariano Vazquez, Jazmin Aguado-Sierra
Published in: The Journal of Precision Medicine: Health and Disease, Issue 3, 2025, ISSN 3050-6328
Publisher: Elsevier BV
DOI: 10.1016/J.PREMED.2025.100011

Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models

Author(s): Pablo Gonzalez-Martin, Federica Sacco, Constantine Butakoff, Ruben Doste, Carlos Bederian, Lilian K. Gutierrez spinosa de los Monteros, Guillaume Houzeaux, Paul A. Iaizzo, Tinen L. Iles, Mariano Vazquez, Jazmin Aguado-Sierra
Published in: PLoS ONE, 2023, ISSN 1932-6203
Publisher: PLoS ONE
DOI: 10.1371/journal.pone.0263639

Performance Assessment of an Electrostatic Filter-Diverter Stent Cerebrovascular Protection Device: Evaluation of a Range of Potential Electrostatic Fields Focusing on Small Particles

Author(s): Beatriz Eguzkitza, José A. Navia, Guillaume Houzeaux, Constantine Butakoff, Mariano Vázquez
Published in: Bioengineering, Issue 11, 2025, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/BIOENGINEERING11111127

Virtual clinical QT exposure-response studies – A translational computational approach

Author(s): Jazmin Aguado-Sierra, Paula Dominguez-Gomez, Ani Amar, Constantine Butakoff, Michael Leitner, Stefan Schaper, Jan M. Kriegl, Borje Darpo, Mariano Vazquez, Georg Rast
Published in: Journal of Pharmacological and Toxicological Methods, Issue 126, 2025, ISSN 1056-8719
Publisher: Elsevier BV
DOI: 10.1016/J.VASCN.2024.107498

Intellectual Property Rights

Other (4)

Computational models for 3D Muscular Electrophysiology and Electromechanics Simulation

Application/Publication number: EP42 48460
Date: 2023-06-14
Applicant(s): ELEM BIOTECH SL

Performance Optimization of Ventricular Assist Devices

Application/Publication number: EP21 383010.2
Date: 2021-11-08
Applicant(s): ELEM BIOTECH SL

Muscular Fibre Estimulation

Application/Publication number: EP24 382251.7
Date: 2024-03-08
Applicant(s): ELEM BIOTECH SL

Muscular Fibre Estimulation

Application/Publication number: EP2025 055223
Date: 2025-02-26
Applicant(s): ELEM BIOTECH SL