ELEM Virtual Heart Populations for Supercomputers

Project Information

ELVIS

Grant agreement ID: 190134524

DOI

10.3030/190134524

Project closed

EC signature date 11 April 2023

Start date 1 March 2023

End date 31 August 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 3 545 852,50

EU contribution

€ 2 482 096,75

Coordinated by

ELEM BIOTECH SL
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

A collection of papers published or on the process to be published on clinical validation.

Publications

Monographic books (2)

Impact of endocrine disruptors from mother's diet on immuno-hormonal orchestration of brain development and introduction of the virtual human twin tool

Author(s): A Fucic1 , A Mantovani, J Vena, M S Bloom , N Sincic , M Vazquez , J Aguado-Sierra
Published in: Reproductive Toxicology
Publisher: ELSEVIER
DOI: 10.1016/j.reprotox.2023.108357

"HPC Framework for Performing in Silico Trials Using a 3D Virtual Human Cardiac Population as Means to Assess Drug-Induced Arrhythmic Risk."" High Performance Computing for Drug Discovery and Biomedicine"

Author(s): Jazmin Aguado-Sierra , Renee Brigham, Apollo K Baron , Paula Dominguez Gomez , Guillaume Houzeaux, Jose M Guerra , Francesc Carreras, David Filgueiras-Rama, Mariano Vazquez, Paul A Iaizzo, Tinen L Iles, Constantine Butakoff
Published in: High Performance Computing for Drug Discovery and Biomedicine
Publisher: Humana, New York, NY
DOI: 10.1007/978-1-0716-3449-3_14

Conference proceedings (1)

A 3D Electromechanical Model of the Human Atria: A Realistic Framework for the Study of Atrial Fibrillation

Author(s): Eva Casoni; Constantine Butakoff; Jazmin Aguado-Sierra; Violeta Puche; Beatriz Trenor; Javier Saiz; Mariano Vazquez
Published in: IEEE Xplore, 2023
Publisher: IEEE
DOI: 10.22489/CINC.2023.200

Peer reviewed articles (6)

Digital twins and Big AI: the future of truly individualised healthcare

Author(s): Peter Coveney, Roger Highfield, Eric Stahlberg, Mariano Vázquez
Published in: npj Digital Medicine, Issue 8, 2025, ISSN 2398-6352
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41746-025-01874-X

A porohyperelastic scheme targeted at High-Performance Computing frameworks for the simulation of the intervertebral disc

Author(s): Dimitrios Lialios, Beatriz Eguzkitza, Guillaume Houzeaux, Eva Casoni, Laura Baumgartner, Jérôme Noailly, Estefano Muñoz-Moya, Benjamin Gantenbein, Mariano Vázquez
Published in: Computer Methods and Programs in Biomedicine, Issue 259, 2024, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/J.CMPB.2024.108493

Replicating clinical placebo effects in computational trials: Bridging the gap between in silico and clinical studies

Author(s): Paula Dominguez-Gomez, Constantine Butakoff, Georg Rast, Borje Darpo, Mariano Vazquez, Jazmin Aguado-Sierra
Published in: The Journal of Precision Medicine: Health and Disease, Issue 3, 2025, ISSN 3050-6328
Publisher: Elsevier BV
DOI: 10.1016/J.PREMED.2025.100011

Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models

Author(s): Pablo Gonzalez-Martin, Federica Sacco, Constantine Butakoff, Ruben Doste, Carlos Bederian, Lilian K. Gutierrez spinosa de los Monteros, Guillaume Houzeaux, Paul A. Iaizzo, Tinen L. Iles, Mariano Vazquez, Jazmin Aguado-Sierra
Published in: PLoS ONE, 2023, ISSN 1932-6203
Publisher: PLoS ONE
DOI: 10.1371/journal.pone.0263639

Performance Assessment of an Electrostatic Filter-Diverter Stent Cerebrovascular Protection Device: Evaluation of a Range of Potential Electrostatic Fields Focusing on Small Particles

Author(s): Beatriz Eguzkitza, José A. Navia, Guillaume Houzeaux, Constantine Butakoff, Mariano Vázquez
Published in: Bioengineering, Issue 11, 2025, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/BIOENGINEERING11111127

Virtual clinical QT exposure-response studies – A translational computational approach

Author(s): Jazmin Aguado-Sierra, Paula Dominguez-Gomez, Ani Amar, Constantine Butakoff, Michael Leitner, Stefan Schaper, Jan M. Kriegl, Borje Darpo, Mariano Vazquez, Georg Rast
Published in: Journal of Pharmacological and Toxicological Methods, Issue 126, 2025, ISSN 1056-8719
Publisher: Elsevier BV
DOI: 10.1016/J.VASCN.2024.107498

Intellectual Property Rights

Other (4)

Performance Optimization of Ventricular Assist Devices

Application/Publication number: EP21 383010.2
Date: 2021-11-08
Applicant(s): ELEM BIOTECH SL

Computational models for 3D Muscular Electrophysiology and Electromechanics Simulation

Application/Publication number: EP42 48460
Date: 2023-06-14
Applicant(s): ELEM BIOTECH SL

Muscular Fibre Estimulation

Application/Publication number: EP2025 055223
Date: 2025-02-26
Applicant(s): ELEM BIOTECH SL

Muscular Fibre Estimulation

Application/Publication number: EP24 382251.7
Date: 2024-03-08
Applicant(s): ELEM BIOTECH SL