Objective
Determining the molecular basis of natural phenotypic variation, including inter-individual susceptibility to common diseases, is a central challenge of post-genome genetics. The rat is a leading model species for research in physiology, pharmacology and toxicology, and for the study of a wide range of common, genetically complex human diseases. Decades of exquisite phenotyping and detailed analyses in rat experimental crosses have led to localization of hundreds of quantitative trait loci (QTLs) contai ning genes that confer susceptibility to complex disease phenotypes. However in common with studies in other organisms, few genes underlying these genetically complex traits have as yet been identified. The availability of the rat genome sequence and g enome-scale technologies, along with the ability to clone fertile adult rats, has substantially advanced the potential for functional genomics research in the rat model. The European Rat Tools for Functional Genomics (EURATools) consortium draws together leading European researchers in rat genetics, pharmacology, toxicology, disease pathophysiology, and genome biology and informatics. The central aim of this project is the development of integrated genome tools that will generate knowledge which can be translated into improvements in healthcare for highly prevalent diseases in the European Union. The EURATools aims will be achieved by integrating high-throughput sequencing and genotyping with informatics; by intensive analysis of phenotypes, gene seq uence and gene expression in congenic strains to identify genes and regulatory pathways for a wide range of rat disease phenotypes; and by establishment of optimised protocols for rat gene targeting. These new resources will significantly improve our und erstanding of complex genetic traits, and will enhance prospects for drug development and strategies for preventing and treating some of the commonest diseases in western societies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences basic medicine toxicology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
N/A LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.