Objective
Endocytic trafficking plays a more active role in the regulation of polypeptide growth factor (GF) signalling than recognized
before. Despite great progress in the description of the endocytic routes and their molecular regulation, we are far from a
complete understanding of the endocytic trafficking of GF receptor (GFR) complexes and to which extent their signalling
activity requires and is modulated by these routes. The EndoTrack project aims at filling this gap by gaining basic
knowledge of the relationship between the endocytic transport and signalling activity of GFRs. EndoTrack combines
leading European interdisciplinary research teams to pursue the following aims:
1. To define the trafficking routes of various GFR complexes in cultured cells with an unprecedented degree of
precision, combining high-throughput microscopy, electrochemiluminescence technology and automated image analysis.
2. To define the molecular machinery responsible for this transport, using proteomics and functional genomics
approaches, and generate proof of concept that trafficking contributes to GF signalling activity in cultured cells.
3. To integrate the information from cultured cells with in vivo studies on animal model systems, in particular
Drosophila, zebrafish, Xenopus and mouse.
4. To test the relevance of the modulation of endocytic trafficking on signal transduction in disease model systems.
Within 4 years, the use of knockdown approaches, reporter cell lines and animals, combined with target validation
proprietary technology from the biotech SMEs, will provide a new generation of assays to measure GFR trafficking
and signalling. These assays will lead to novel key regulatory components, and therefore a new generation of
diagnostic markers and potential targets for modulation of GF signalling and for the treatment of human diseases.
EndoTrack's translational research will thus strengthen the innovation potential of European biotech and pharmaceutical
industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MÜNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.