Objective
Advances in genomics have resulted in the development of new protein-based drugs. This trend will increase in the next decade. Delivery technologies for these drugs must be designed to surmount biochemical and anatomical barriers to safely permit their passage to an intended site. Targeted delivery of protein-based drugs is limited by a series of barriers, among which, three are of critical importance: 1) Rational transport of protein-based drugs across cellular membrane 2) Control of the inter- and intra-cellular routes taken by these drugs 3) Understanding of the structural characteristics of the protein-based drugs and of their targets to achieve efficiency and specificity. Advances to overcome these barriers will lead to develop new, safer and more effective drugs by reducing undesirable side effects. To that end, the Nano4drugs consortium integrates top-level teams across Europe to develop an innovative challenging frontier bio-technology device ideally suited for targeted delivery of protein-based drugs. The device consists of bio-compatible non-bleachable fluorescent diamond nano-particles that can be grafted with both cell-penetrating peptides and protein-based drugs. As a proof of concept, Nano4drugs will target microtubules in two different biological contexts, neuron and cancer. The protein-based drugs will consist of anti-microtubules peptides recently discovered in one team of Nano4Drug, and of new ones that will be tested during the STREP with the help of post-genomic computer-based system of choices designed to guide and improve the development of protein-based drugs. At the end of this STREP, Nano4Drugs will provide Europe with a better understanding of ways to overcome protein-based drug delivery barriers. In achieving its objectives, Nano4Drugs will also deliver new potential treatments for societal health diseases such as neurological degenerative diseases and cancer. Application expected will increase European competitiveness and economy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences biochemistry biomolecules
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-LIFESCIHEALTH-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.