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Design of a vaccine to immunize neonates against GBS infections through a durable maternal immune response

Objective

Direct vaccination cannot prevent diseases that affect neonates in the first days of life. Group B Streptococcus (GBS) is the major cause of neonatal septicemia and meningitis affecting up to one in every thousand live births. Over 80% of cases occur in the first 7 days after birth and the remaining 20% of disease occurs between 8-90 days after birth. Studies carried out in the USA indicate that high titres of maternal antibody to GBS capsular polysaccharides (CPS) correlate with reduced risk of disease in neonates suggesting that maternal immunization may be an effective strategy for delivery of a protective immune response to the child in this early period. The overall objective of this proposal is to design immunization strategies capable of inducing strong durable and placentally transferable protective immune responses against GBS in women in order to fill this gap in early infancy when direct immunization is not possible. Starting with the genome sequence of 8 strains of GBS, Novartis scientists have identified three proteins that confer protection against lethal challenge in neonatal mice from immunized females. Combinations of CPS conjugates plus the recombinant proteins conferred protection against 12 of 12 GBS strains representing the major disease causing serotypes. In order to translate this research into a viable vaccine it will be necessary to identify appropriate adjuvant and delivery systems capable of inducing a protective response which will last through pregnancy. In order to select the serotypes of CPS to include in the vaccine, it will be necessary to understand the serotype distribution of GBS disease in Europe. Furthermore, an immune surrogate of protection will be required to replace efficacy trials. This proposal will address these issues by evaluating adjuvant and delivery in mouse models of disease and by analysis of maternal antibody levels and strain characteristics in cases versus controls obtained from several countries in Europe

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /social sciences/sociology/demography/fertility
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/genetics and heredity/genome

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

GLAXOSMITHKLINE VACCINES SRL
Address
Via Fiorentina 1
53100 Siena
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 907 800
Administrative Contact
Francesco Gulli (Dr.)

Participants (9)

ISTITUTO SUPERIORE DI SANITA
Italy
EU contribution
€ 459 900
Address
Viale Regina Elena 299
00161 Roma
Activity type
Research Organisations
Administrative Contact
Rosa Maria Martoccia (Dr.)
Public Health England an Executive Agency of the Dept of Health
United Kingdom
EU contribution
€ 538 640
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Peter S. Borriello (Prof.)
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE
Belgium
EU contribution
€ 339 650
Address
Sart Tilman B35
4000 Liege
Activity type
Research Organisations
Administrative Contact
Louis Pol (Dr.)
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 282 400
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Arturo D. Dominguez Fernandez (Dr.)
STATNI ZDRAVOTNI USTAV
Czechia
EU contribution
€ 289 400
Address
Srobarova 48
10042 Praha 10
Activity type
Research Organisations
Administrative Contact
Jaroslav Volf (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 346 250
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerhard Henninger
NATIONAL CENTER OF INFECTIOUS AND PARASITIC DISEASES
Bulgaria
EU contribution
€ 209 000
Address
Blvd. Yanko Sakazov 26
1504 Sofia
Activity type
Research Organisations
Administrative Contact
Bogdan Petrunov (Prof.)
AARHUS UNIVERSITET
Denmark
EU contribution
€ 342 320
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lizzie Jensen (Ms.)
ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU
Italy
EU contribution
€ 481 100
Address
Via Fiorentina 151
53100 Siena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Aldo Tagliabue (Dr.)