Final Report Summary - NBO (Novel Biomimetic Organocatalysts)
We also developed new reactions between enolisable anhydrides and electrophiles. These reactions were known for some time, but no catalysts were available for them, meaning that efficient and (more importantly) asymmetric versions of these processes were not available. We discovered a new way of promoting these reactions using a mild form of bifunctional catalyst (one which activates the nucleophilic and electrophilic reaction components simultaneously) - which allowed the cycloaddition of enolisable anhydrides and a variety of electrophiles with excellent enantio- and diastereocontrol at operationally convenient temperatures. The products which now can be synthesised in enantioenriched form are diverse and belong to some of the most useful and medicinally relevant core units in organic/medicinal chemistry.