Objective
The CARS EXPLORER seeks to demonstrate the concept of innovative light-based contrasting technologies for functional in situ imaging in life science and biomedical research. Our ultimate goal is to develop an endoscope based on non-linear optics (NLO) and laser pulse phase shaping. Non linear laser pulse interactions with living tissues provide unique possibilities, such as an absence of sample preparation, direct multiparametric visualization with molecular specificity and cellular resolution, and deep sample penetration. Nevertheless, the effective transfer of NLO to biomedical applications faces major technological challenges related to the delivery of ultra-short laser pulses, the weakness of the signal produced in biological samples and the difficulty in interpreting generated contrasts. Therefore, the CARS EXPLORER interdisciplinary consortium includes partners with expertise ranging from optical physics to the clinic. The work plan is split into 5 RTD workpackages: three are intended to overcome specific technological problems with (1) the development of dedicated methodology using phase shaping for NLO imaging of deep biological tissues, (2) the development of specific photonic crystal fibre optics for the excitation, delivery and collection of NLO signals, and (3) the extraction of relevant information from NLO signals generated in biological tissues. The two other workpackages will determine the assets and constraints in NLO imaging through appropriate experimental biological models. These models will also assess each technological improvement made on the microscope and endoscope prototypes. Last, to bring the concept to the diagnostic level, we will explore the molecular and morphological NLO signatures associated with tumor development in skin cancer. In addition to the challenge of developing pulse shaped NLO-based endoscope technology, this project will have strategic and economic impact by providing a non-invasive functional exploration method.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer
- natural sciences physical sciences optics microscopy
- natural sciences physical sciences optics fibre optics
- natural sciences physical sciences optics nonlinear optics
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2007-A
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.