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Mycobacterium tuberculosis W-Beijing genetic diversity and differential virulence and host immune responses

Objective

Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, together with host genetic factors, contribute to such differences between infected individuals. The M. tuberculosis W-Beijing lineage is one of the most successful mycobacterial families, in terms of morbidity and mortality. This lineage has been detected almost worldwide. The predominance of the W-Beijing lineage probably results from genetic advantages, including unidentified virulence factors and the induction/modification of specific host responses not yet thoroughly investigated. This project aims to unravel the links between differential host responses to M. tuberculosis infection and mycobacterial genetic diversity and virulence at the global genomic and post-genomic levels within the W-Beijing family, and between the W-Beijing family and other M. tuberculosis families, in order to improve our understanding of the epidemiological success of this particular lineage. Overall, this work will provide the scientific and clinical community with pioneering research and novel information increasing our understanding of the impact of M. tuberculosis strain diversity on virulence, immune response and pathology. This project will complement and expand the efforts of several internationally recognized laboratories to unveil new genotype-phenotype associations by integrating complex phenotypic data and information about mycobacterial genetic diversity.

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Research Organisations
EU contribution
€ 372 515
Administrative Contact
Armelle Barelli (Ms.)

Participants (10)

INSERM TRANSFERT SA
France
EU contribution
€ 187 690
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Jammayrac (Mr.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 642 250
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Birgit Gieding (Ms.)
UNIVERSIDAD DE ZARAGOZA
Spain
EU contribution
€ 320 000
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Oscar Lopez Lorente (Mr.)
FUDAN UNIVERSITY
China
EU contribution
€ 205 900
Address
Handan Road 220
200433 Shanghai
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Xue-Lei Lin (Prof.)
INSTITUT PASTEUR KOREA
South Korea
EU contribution
€ 375 009
Address
Hawolgok Dong, Seongbuk Gu 39-1
136 791 Seoul
Activity type
Research Organisations
Administrative Contact
Sungeun Kim (Ms.)
INTEGRAGEN SA
France
EU contribution
€ 12 067
Address
Rue Henri Desbrueres Genopole 5
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Court (Mr.)
RUJIN HOSPITAL, SHANGAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
China
EU contribution
€ 352 059
Address
197 Rui Jin Er Road
200025 Shanghai
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Yiping Xu (Ms.)
SHANGAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION
China
EU contribution
€ 62 310
Address
West Zhongshan Road
200336 Shangai
Activity type
Research Organisations
Administrative Contact
Hangping Yang
Eurofins Genomics Europe Sequencing GmbH
Germany
EU contribution
€ 40 000
Address
Jakob Stadler Platz 7
78467 Konstanz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Pohl
INSTITUT PASTEUR
France
EU contribution
€ 397 200
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)