Objective Improvements in TB control require the development of new tools for rapid and accurate diagnosis and intervention. This development is likely to benefit from more detailed knowledge of microbe-host relationships during infection. Following M. tuberculosis infection, only 5-10% of immunocompetent individuals develop TB. It is increasingly thought that the virulence of the infecting strain, together with host genetic factors, contribute to such differences between infected individuals. The M. tuberculosis W-Beijing lineage is one of the most successful mycobacterial families, in terms of morbidity and mortality. This lineage has been detected almost worldwide. The predominance of the W-Beijing lineage probably results from genetic advantages, including unidentified virulence factors and the induction/modification of specific host responses not yet thoroughly investigated. This project aims to unravel the links between differential host responses to M. tuberculosis infection and mycobacterial genetic diversity and virulence at the global genomic and post-genomic levels within the W-Beijing family, and between the W-Beijing family and other M. tuberculosis families, in order to improve our understanding of the epidemiological success of this particular lineage. Overall, this work will provide the scientific and clinical community with pioneering research and novel information increasing our understanding of the impact of M. tuberculosis strain diversity on virulence, immune response and pathology. This project will complement and expand the efforts of several internationally recognized laboratories to unveil new genotype-phenotype associations by integrating complex phenotypic data and information about mycobacterial genetic diversity. Fields of science social sciencessociologydemographymortalitymedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepathology Keywords Genotype/phenotype associations Microbial diversity Mycobacterium tuberculosis Tuberculosis W/Beijing family Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.2-2 - Highly innovative approaches for research into host-pathogen interaction in tuberculosis Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS EU contribution € 372 515,00 Address RUE MICHEL ANGE 3 75794 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Armelle Barelli (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSERM TRANSFERT SA France EU contribution € 187 690,00 Address 10 RUE D'ORADOUR-SUR-GLANE - PARISANTE CAMPUS 75015 PARIS See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Louis Jammayrac (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 642 250,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Birgit Gieding (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE ZARAGOZA Spain EU contribution € 320 000,00 Address CALLE PEDRO CERBUNA 12 50009 Zaragoza See on map Region Noreste Aragón Zaragoza Activity type Higher or Secondary Education Establishments Administrative Contact Oscar Lopez Lorente (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUDAN UNIVERSITY China EU contribution € 205 900,00 Address HANDAN ROAD 220 200433 SHANGHAI See on map Activity type Higher or Secondary Education Establishments Administrative Contact Xue-Lei Lin (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT PASTEUR KOREA South Korea EU contribution € 375 009,00 Address HAWOLGOK DONG, SEONGBUK GU 39-1 136 791 SEOUL See on map Activity type Research Organisations Administrative Contact Sungeun Kim (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INTEGRAGEN SA France EU contribution € 12 067,00 Address RUE HENRI DESBRUERES GENOPOLE 5 91000 EVRY See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patrick Court (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RUJIN HOSPITAL, SHANGAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE China EU contribution € 352 059,00 Address 197 RUI JIN ER ROAD 200025 SHANGHAI See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Yiping Xu (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SHANGAI MUNICIPAL CENTER FOR DISEASE CONTROL AND PREVENTION China EU contribution € 62 310,00 Address west Zhongshan Road 200336 SHANGAI See on map Activity type Research Organisations Administrative Contact Hangping Yang Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROFINS GENOMICS EUROPE PHARMA AND DIAGNOSTICS PRODUCTS & SERVICES SANGER PCR GMBH Germany EU contribution € 40 000,00 Address JAKOB STADLER PLATZ 7 78467 Konstanz See on map Region Baden-Württemberg Freiburg Konstanz Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Pohl Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT PASTEUR France EU contribution € 397 200,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nadia Khelef (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data