Objective Neurotrophins are growth factors including NGF, BDNF, NT-3 and NT-4, which function in cell survival, differentiation, apoptosis, axonal and dendritic growth, and plasticity in the nervous system. Additionally, BDNF has been implicated in human brain pathologies, such as depression, Alzheimer, Huntington, Parkinson, etc. Neurotrophins bind to two different sets of receptors, Trk and p75 receptors, to mediate their functions. Trk activation leads to its phosphorylation in tyrosine and the phosphorylated residues work as docking sites for different adaptor molecules, such as Shc, PLC-γ, FRS-2, SH2B and APS. Recently, a new molecule, ARMS/Kidins220, has been described in association with Trk receptors. ARMS is tyrosine phosphorylated in primary hippocampal and cortical neurons in response to neurotrophins, and is involved in the sustained MAPK mediated by neurotrophins. My work hypothesis is that ARMS/Kidins220 may be an important molecule in neurotrophin functions. For this reason, we propose the study of ARMS/Kidins220 in the differentiation, dendritic branching and neuronal synaptic plasticity mediated by BDNF. The study will be carried out using biochemical and cellular techniques together with molecular biology and genetic approaches. The detailed study of ARMS/Kidins220 will provide a better understanding of the neurotrophin functions as well as the molecular mechanisms that regulate neurotrophin actions and its potential role in nervous system pathologies. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicinepathologymedical and health sciencesbasic medicineneurologyparkinsonnatural sciencesbiological sciencesmolecular biology Keywords Neurobiology Neurophysiology Neurosciences Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants" Call for proposal FP7-PEOPLE-2007-4-3-IRG See other projects for this call Funding Scheme MC-IRG - International Re-integration Grants (IRG) Coordinator UNIVERSIDAD DE SALAMANCA EU contribution € 100 000,00 Address CALLE PATIO DE ESCUELAS 1 37008 Salamanca Spain See on map Region Centro (ES) Castilla y León Salamanca Activity type Higher or Secondary Education Establishments Administrative Contact Miguel Merchan Cifuentes (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
