Molecular mechanisms underlying BDNF functions in the brain: role of ARMS protein

Informations projet

NEUROTROPHINS-ARMS

N° de convention de subvention: 201029

Projet clôturé

Date de début 1 Janvier 2008

Date de fin 31 Decembre 2011

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 100 000,00

Contribution de l’UE € 100 000,00

Coordonné par

UNIVERSIDAD DE SALAMANCA
Espagne

Objectif

Neurotrophins are growth factors including NGF, BDNF, NT-3 and NT-4, which function in cell survival, differentiation, apoptosis, axonal and dendritic growth, and plasticity in the nervous system. Additionally, BDNF has been implicated in human brain pathologies, such as depression, Alzheimer, Huntington, Parkinson, etc. Neurotrophins bind to two different sets of receptors, Trk and p75 receptors, to mediate their functions. Trk activation leads to its phosphorylation in tyrosine and the phosphorylated residues work as docking sites for different adaptor molecules, such as Shc, PLC-γ, FRS-2, SH2B and APS. Recently, a new molecule, ARMS/Kidins220, has been described in association with Trk receptors. ARMS is tyrosine phosphorylated in primary hippocampal and cortical neurons in response to neurotrophins, and is involved in the sustained MAPK mediated by neurotrophins. My work hypothesis is that ARMS/Kidins220 may be an important molecule in neurotrophin functions. For this reason, we propose the study of ARMS/Kidins220 in the differentiation, dendritic branching and neuronal synaptic plasticity mediated by BDNF. The study will be carried out using biochemical and cellular techniques together with molecular biology and genetic approaches. The detailed study of ARMS/Kidins220 will provide a better understanding of the neurotrophin functions as well as the molecular mechanisms that regulate neurotrophin actions and its potential role in nervous system pathologies.

Champ scientifique (EuroSciVoc)

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• sciences naturelles › sciences biologiques › neurobiologie
• sciences médicales et de la santé › médecine fondamentale › neurologie › démence › alzheimer
• sciences médicales et de la santé › médecine fondamentale › pathologie
• sciences médicales et de la santé › médecine fondamentale › neurologie › parkinson
• sciences naturelles › sciences biologiques › biologie moléculaire

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Mots‑clés

• Neurobiology
• Neurophysiology
• Neurosciences

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants"

Appel à propositions

FP7-PEOPLE-2007-4-3-IRG
Voir d’autres projets de cet appel

Régime de financement

MC-IRG -

Coordinateur

UNIVERSIDAD DE SALAMANCA

• Contribution de l’UE: € 100 000,00
• Adresse: CALLE PATIO DE ESCUELAS 1 ; 37008 Salamanca ; Espagne
• Région: Centro (ES) › Castilla y León › Salamanca
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: Aucune donnée