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Adipokines as Drug Targets to Combat Adverse Effects of Excess Adipose Tissue

Objective

Obesity represents the major risk factor for the cardiometabolic syndrome, which is an epidemic disease that generates a severe global socio-economic burden for the public health systems. Enhanced production of proinflammatory adipocytokines by expanded adipose tissue is now considered as a key event in the pathogenesis of this syndrome. This process involves i) the systemic release of adipokines, preferentially by visceral abdominal fat and ii) the paracrine, adipokine-mediated crosstalk between periorganic fat and different organs including skeletal and cardiac muscle. Members of the ADAPT consortium have pioneered this novel view of adipose tissue as an active endocrine organ. However, there is very limited knowledge if adipokines and their downstream signalling pathways may represent “drugable” targets potentially opening new avenues to combat the devastating complications linked to obesity and the cardiometabolic syndrome. Therefore, the major goal of this project is to identify novel or existing adipocytokines as drug targets that could be used to reverse obesity-associated inflammation and adverse reactions related to excess fat, as outlined in the work programme. For this purpose the mustidisciplinary ADAPT consortium has been formed which integrates basic and clinical science, bioinformatics, in silico drug design and the specific expertise of a large pharmaceutical company. To reach the objectives, a stepwise strategy will be used including i) the identification of novel adipocytokines and the cellular sources and regulation of adipokine production, ii) the analysis of intraorgan crosstalk within adipose tissue which plays a pivotal role in adipose tissue inflammation, iii) the assessment of interorgan crosstalk with a focus on skeletal and cardiac muscle and the role of brown fat and iv) the pharmacological and clinical evaluation of adipokines as drug targets and potential biomarkers.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/basic medicine/medicinal chemistry

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

DEUTSCHE DIABETES FORSCHUNGSGESELLSCHAFT EV
Address
Auf M Hennekamp 65
40225 Duesseldorf
Germany
Activity type
Research Organisations
EU contribution
€ 615 480
Administrative Contact
Hans-Joachim Liebe (Mr.)

Participants (11)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 419 400
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Klas Karlsson (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 418 200
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Laurent Vezinhet (Mr.)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 417 000
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pia Bjeren-Fürstenbach (Ms.)
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
France
EU contribution
€ 299 760
Address
Place Jussieu 4
75252 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephanie Rossard (Dr.)
UNIVERZITA KARLOVA
Czechia
EU contribution
€ 212 400
Address
Ovocny Trh 560/5
116 36 Praha 1
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jana Muzikova (Ms.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fraessdorf (Ms.)
LABORATOIRE GLAXOSMITHKLINE
France
EU contribution
€ 44 000
Address
Route De Versailles 100
78160 Marly Le Roi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Agnes Meisel (Ms.)
PHYSIOGENEX SAS
France
EU contribution
€ 120 720
Address
Rue Pierre Et Marie Curie- Prologue Biotech
31682 Labege Innopole
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Guillaume Costecalde (Mr.)
MOLECULAR EXTENDED DISTRIBUTION IN INFORMATION TECHNOLOGY
France
EU contribution
€ 89 040
Address
2 Rue De Belvedere
91120 Palaiseau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Francois Delfaud (Mr.)
MABTECH AB
Sweden
EU contribution
€ 125 520
Address
Augustendalsv 19
13128 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kjell Oestrand (Mr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 218 760
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Norbert Langhorst (Mr.)