Objective IMECS is a proposal of the FLUSECURE network aimed at combating the threat of new and re-emerging forms of highly pathogenic influenza in its first stages of a disease by identifying mechanisms of protection that are essential for a solid immune response to avian influenza. IMECS is uniquely featured by correlating research in humans directly to protection from influenza. The IMECS initiative was introduced since the recent H5N1 avian influenza vaccine trials results have shown limited success in inducing a protective immune response as compared to the standard human influenza vaccines. This despite large investments and multiple vaccine formulations tested. These results make clear that the mechanisms of immunity for avian influenza are inherently different from those for human/seasonal influenza. The IMECS initiative aims to elucidate these mechanisms and aims to provide essential knowledge for development of breakthrough pandemic vaccines as a result. The initiative thereto boosts the development of AI-correlates of protection for the clinical screening of vaccine candidates in healthy adults and in different target groups, the origin of subclinical AI infection in humans, as well as a research programme for the screening of vaccine candidates in vitro. The following research objectives are pursued: - Determining the basis of the homologous and non-homologous mechanisms of protection for avian influenza; - Determine the mechanisms of protection in specific target groups, including infants and the elderly; - Determining the AI-specific response after vaccination in clinical trial studies. IMECS combines the knowledge of leading European universities and research centres. The multidisciplinary consortium has the resources, skills and knowledge to realize the objectives of this collaborative research project.The consortium consists of 6 partners and two subcontractors from five different European countries and one disease endemic country (SICA) Fields of science medical and health scienceshealth sciencesinfectious diseasesRNA virusesinfluenzamedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Keywords Homologous Homologous non-homologous mechanisms of protection influenza target-groups correlates of protection correlates of protection influenza target-groups mechanisms of protection non-homologous Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.3-2 - Identifying immunological mechanisms of protection for influenza vaccines Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Address Antonie van leeuwenhoeklaan 9 3721 MA Bilthoven Netherlands See on map Region West-Nederland Utrecht Utrecht Activity type Research Organisations Administrative Contact Marjon Hartwigsen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 365 226,00 Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all VIEN VE SINH DICH TE TRUNG UONG Vietnam EU contribution € 150 584,00 Address Yersin street hai ba trung 1 1000 Hanoi See on map Activity type Higher or Secondary Education Establishments Administrative Contact Duc Anh Dang (Prof.) Links Contact the organisation Opens in new window Website Opens in new window TERVEYDEN JA HYVINVOINNIN LAITOS Finland EU contribution € 492 975,00 Address Mannerheimintie 166 00271 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Jaakko Penttinen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 399 750,00 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Sonja Croes (Ms.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA Switzerland EU contribution € 388 379,00 Address Via francesco chiesa 5 6500 Bellinzona See on map Region Schweiz/Suisse/Svizzera Ticino Ticino Activity type Research Organisations Administrative Contact Fosca Bognuda (Ms.) Links Contact the organisation Opens in new window Website Opens in new window ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 240 845,00 Address Viale regina elena 299 00161 Roma See on map Region Centro (IT) Lazio Roma Administrative Contact Rosa Maria Martoccia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window FONDAZIONE ANDREA CESALPINO* Italy EU contribution € 111 030,00 Address Via sicilia 169 00187 Roma See on map Activity type Higher or Secondary Education Establishments Administrative Contact Luigino Mangiapelo (Mr.) Links Contact the organisation Opens in new window MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT Participation ended Netherlands EU contribution € 648 498,00 Address Parnassusplein 5 2500 EJ Den haag See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Administrative Contact Ernst Soethout (Mr.) Links Contact the organisation Opens in new window
