Objective Nanoparticles (NP) have unique, potentially beneficial properties, but their possible impact on human health has not been adequately assessed. The main goal of this proposal is to develop alternative high-throughput testing strategies using in vitro and in silico methods to assess the toxicological profile of NP used in medical diagnostics. Our specific aims are to: 1. Define NP properties and fully characterize NP to be used 2. Study NP interactions with molecules, cells and organs and develop in vitro methods to study the toxicological potential of NP 3. Validate in vitro findings in short-term in vivo models and study particle effects in animals and (ex vivo) in humans to assess individual susceptibility to NP 4. Develop in silico models of NP interactions Experimental work is structured in 4 WPs to address NP characterisation and key elements in evaluation of NP uptake, exposure and toxicology. NANOTEST integrates the investigation of toxicological properties and effects of NP in several target systems by developing a battery of in vitro assays using cell cultures, organotypic cell culture and small organ fragments (ex vivo) derived from different biological systems; blood, vascular system, liver, lung, placenta, digestive and central nervous systems. As NP action is likely to involve oxidative stress we will focus on the cross-cutting areas of inflammation, cellular toxicity, immunotoxicity, genotoxicity and related endpoints. Following development of SOP and generation of a common database and in parallel with in silico assays (QSAR, PBPK modelling), NanoTest will evaluate toxic effects and interactions of NP used in nanomedicine. Results will be validated in an experimental ethically approved in vivo model. The most advanced and standardised techniques will be adapted for automation and prepared for validation by ECVAM. Separate WPs will be dedicated to dissemination and to effective administrative and scientific management. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesclinical medicineobstetricsengineering and technologynanotechnologynano-materialsmedical and health sciencesbasic medicinetoxicology Keywords (Q)SAR Alternative tests Alterntaive Alterntaive tests In vitro In vitro toxicity Medical Medical devices Nanoparticles QSAR devices tests toxicity Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-1.3-4 - Alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator STIFTELSEN NILU Address Instituttveien 18 2007 Kjeller Norway See on map Region Norge Oslo og Viken Viken Activity type Research Organisations Administrative Contact Maria Dusinska (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 578 430,00 Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUTE OF OCCUPATIONAL MEDICINE United Kingdom EU contribution € 130 593,00 Address Research avenue north, riccarton 45 EH14 4AP Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Research Organisations Administrative Contact Susy Scarisbrick (Ms.) Links Contact the organisation Opens in new window Website Opens in new window CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS Switzerland EU contribution € 215 750,00 Address Rue du bugnon 21 1011 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Bernard Gmünder (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Université Paris Diderot-Paris 7 France EU contribution € 193 250,00 Address Rue thomas mann F-75205 / 13 Paris See on map Activity type Higher or Secondary Education Establishments Administrative Contact Muriel Maurice (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITY HOSPITALS BRISTOL AND WESTON NHS FOUNDATION TRUST United Kingdom EU contribution € 188 196,00 Address Marlborough street trust headquarters BS13NU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Research Organisations Administrative Contact Margaret Saunders (Dr.) Links Contact the organisation Opens in new window Website Opens in new window JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgium EU contribution € 463 842,00 Address Rue de la loi 200 1049 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Administrative Contact Raymond Crandon (Mr.) Links Contact the organisation Opens in new window Website Opens in new window "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Greece EU contribution € 150 050,00 Address End of patriarchou grigoriou e and 27 neapoleos street 15341 Agia paraskevi See on map Region Αττική Aττική Βόρειος Τομέας Αθηνών Activity type Research Organisations Administrative Contact Stella Martaki (Ms.) Links Contact the organisation Opens in new window Website Opens in new window SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE Slovakia EU contribution € 339 750,00 Address Limbova 12 833 03 Bratislava See on map Region Slovensko Bratislavský kraj Bratislavský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Milan Cagáň (Mr.) Links Contact the organisation Opens in new window Website Opens in new window KOBENHAVNS UNIVERSITET Denmark EU contribution € 188 670,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES S.A. Spain EU contribution € 308 508,99 Address C/baldiri reixac 10-12 08028 Barcelona See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Luis Ruiz Avila (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITA CA' FOSCARI VENEZIA Italy EU contribution € 158 520,00 Address Dorsoduro 3246 30123 Venezia See on map Region Nord-Est Veneto Venezia Activity type Higher or Secondary Education Establishments Administrative Contact Emanuele Argese (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ACONDICIONAMIENTO TARRASENSE ASSOCIACION Spain EU contribution € 78 823,01 Address Carrer de la innovacio 2 08225 Terrassa See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Izabel Alfany (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
