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European Network for Genetic and Genomic Epidemiology

Objective

ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a substantial number of large and well-characterised European (and other) sample sets of various types. The initial focus will be an integrated analysis of >80,000 genomewide association scans available to the consortium, thereby identifying the large number of novel disease-susceptibility variants undetectable in individual studies. Early studies will concentrate on metabolic and cardiovascular phenotypes, with subsequent expansion to apply the methods developed and lessons learned in other disease areas. The ENGAGE framework has been designed to be adaptable to advances that enable global analyses of other sources of genomic variation (eg structural and epigenetic variants), and to broadening of the phenotypic spectrum (to genomic endophenotypes in particular). The clinical and public health relevance of the novel disease- and trait-susceptibility variants we identify will be evaluated using the breadth and diversity of ENGAGE cohorts (DNAs and serum/plasma samples from over 600,000 individuals). The final step will be to effect responsible clinical translation of our major findings. As well as advances in the understanding of disease pathogenesis which may underpin novel therapeutic advances, we expect to provide clear proof-of-principle that genetic and genomic discoveries can be translated into diagnostic indicators for common diseases with the capacity to stratify risk, monitor disease progression and predict and monitor therapeutic response. ENGAGE has assembled the best researchers, clinical samples and statistical and technical expertise in Europe to realise these goals.

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

HELSINGIN YLIOPISTO
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 407 137,69
Administrative Contact
Kaisa Ainala (Ms.)

Participants (25)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 1 159 464
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edward Gibbs (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 661 993
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Administrative Contact
Keith Williamson (Mr.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 395 700
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colleen Spence (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 376 184,50
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
ILLUMINA CAMBRIDGE LTD
United Kingdom
EU contribution
€ 148 348
Address
Illumina Centre 19 Granta Park
CB21 9DF Great Abington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Julie Fordham (Ms.)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 825 509,90
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Ouwerkerk (Ms.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 337 536
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Koos (J.Th.N.) Lubbe (Dr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 737 237,57
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 265 697,24
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agneta Häggström (Ms.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 774 750
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lennart Råstam (Prof.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 504 035,28
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lillebil Andersson (Ms.)
KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 116 130
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
åke Eriksson (Mr.)
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 662 100
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
Administrative Contact
Jennifer Harris (Dr.)
TARTU ULIKOOL
Estonia
EU contribution
€ 166 692
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andres Metspalu (Prof.)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 932 888,50
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Björgvin Richardsson (Mr.)
Ontario Institute for Cancer Research
Canada
EU contribution
€ 52 176
Address
661 University Avenue, Suite 510
M5G 0 A3 Toronto, Ontario
Activity type
Research Organisations
Administrative Contact
Jane Van Alphen (Ms.)
UNIVERSITE DE MONTREAL

Participation ended

Canada
EU contribution
€ 35 391,72
Address
Cp 6128 Station Centre Ville
H3C3J7 Montreal
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Denise Avard (Dr.)
FUNDACIO CENTRE DE REGULACIO GENOMICA
Spain
EU contribution
€ 374 706
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Oscar Fraile (Mr.)
UNIVERSITY OF LEICESTER
United Kingdom
EU contribution
€ 510 905,52
Address
University Road
LE1 7RH Leicester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Adams (Ms.)
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 300 192
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriele Huhn (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 322 930,80
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Robinson (Mr.)
QUEENSLAND INSTITUTE OF MEDICAL RESEARCH
Australia
Address
Herston Road, 300
QLD 4006 Herston
Activity type
Research Organisations
Administrative Contact
Donna Hancock (Ms.)
GENOME RESEARCH LIMITED
United Kingdom
EU contribution
€ 645 888
Address
The Gibbs Building, Euston Road 215
NW1 2BE London
Activity type
Research Organisations
Administrative Contact
David Davison (Mr.)
LATVIJAS UNIVERSITATES MATEMATIKAS UN INFORMATIKAS INSTITUTS
Latvia
EU contribution
€ 159 798
Address
Raina Bulvaris 29
1459 Riga
Activity type
Research Organisations
Administrative Contact
Inara Opmane (Ms.)
ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY
Canada
EU contribution
€ 126 608,28
Address
845 Sherbrooke Street West
H3A0G4 Montreal
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Olga Naiberguer (Ms.)