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Genetic Analysis of the host-pathogen interaction in tuberculosis

Objective

We propose to extend an existing collection of DNA extracts from TB patients and their corresponding TB DNA to establish the world’s largest resource of extracts from a population of TB patients and 5000 ethnically matched healthly controls. The bank will comprise 5000 DNA host DNA extracts paired the DNA and cultures of the strain of Mycobacterium tuberculosis causing their disease. We will perform a genome-wide scan to discover human genes predisposing to TB. We will then localise causal variants and study their role in a case-control population TB sample from another high incidence country in Africa ,Ghana. We will extensively characterise TB strains from a population in Russia using spoligotyping, minisatellite analysis, and SNP analysis of genes putatively associated with virulence and analyse the host-pathogen interaction identifying mycobacterial genes affecting the course of TB, the innate response to TB and outcome at a genetic level. Based on the existing collection of matched host-pathogen DNA we will perform functional experiments of the role of identified mycobacterial factors such as PE variants and the effect of this variation on aspects of innate immunity as influenced by newly-identified TB-associated genes.

Field of science

  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

QUEEN MARY UNIVERSITY OF LONDON
Address
327 Mile End Road
E1 4NS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 246 130
Administrative Contact
Francis Drobniewski (Prof.)

Participants (4)

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 662 998
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Barker (Ms.)
SMITTSKYDDSINSTITUTET
Sweden
EU contribution
€ 202 068
Address
Nobels Vaeg 18
17182 Solna
Activity type
Research Organisations
Administrative Contact
Hans Ottosson (Mr.)
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
Germany
EU contribution
€ 303 318
Address
Bernhard Nocht Strasse 74
20359 Hamburg
Activity type
Research Organisations
Administrative Contact
Udo Gawenda (Mr.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 423 750
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jutta Landvogt