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Genetic Analysis of the host-pathogen interaction in tuberculosis

Final Report Summary - TB-EURO-GEN (Genetic analysis of the host-pathogen interaction in tuberculosis)

The goal of the TB-EURO-GEN project is to better understand host-TB pathogen interactions and the factors underlying susceptibility through a genetic and phenotype analysis of host related factors leading to active pulmonary TB and the corresponding bacterial isolate in a European (Russian) population. Significant findings in this population will be evaluated in an African population.

This approach will lead to the discovery of genes involved in susceptibility / resistance to TB in humans. Deciphering effects of the natural variation between M. tuberculosis strains will help to identify virulence factors, and influence prognosis for TB patients. These results will improve our understanding of TB pathogenesis and may have impact on TB vaccine research, opening new targets for TB prevention.