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MULTIMODAL SKIN INSPECTION WITH HYBRID ACOUSTIC & OPTICAL SPECTROSCOPIC IMAGING

Objective

The incidence of skin cancer in Europe, US, and Australia is rising rapidly. One in five will develop some form of skin cancer during the lifetime. A person has a 1:33 chance to develop melanoma, the most aggressive skin cancer. Melanoma is the second most common cancer in women aged 20-29, and the sixth most common cancer in men and women. In 2007, more than 1 million new cases will be diagnosed in the US alone. About 90% of skin cancers are caused by ultraviolet (UV) sun light. The World Health Organization estimates that 60,000 people will die this year from too much sun: 48,000 from melanoma and 12,000 from other skin cancer. A significant improvement of the current diagnostic tools of dermatologists is required in order to identify dermal disorders at a very early stage as well as to monitor directly the effects of treatment. We suggest within this proposal the development of a non-invasive multimodal hybrid imaging system with the capability to perform non-invasive high resolution three-dimensional clinical (i) two-photon imaging with time-correlated single photon detection, (ii) autofluorescence lifetime imaging, (iii) high-frequency acoustical imaging with novel miniaturized multiple detector arrays, and (iv) optoacoustical imaging using ultrashort near infrared (NIR) laser pulses. This novel multimodal approach will provide a wide-field “acoustic/optoacoustic” view with quantitative depth information of the dermatological lesion as well as a close “optical” look into particular intratissue compartments with quantitative hyperspectral information and subcellular resolution. A successful project will provide a novel unique tool for early diagnosis and treatment control of skin cancer and skin disease and will significantly contribute to the improvement of the European health care system.

Field of science

  • /medical and health sciences/clinical medicine/dermatology/melanoma
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/skin cancer
  • /natural sciences/physical sciences/optics/laser physics

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 712 372
Administrative Contact
Andrea Zeumann (Ms.)

Participants (5)

JENLAB GMBH
Germany
EU contribution
€ 933 400
Address
Nerkewitzer Strasse 18
07778 Neuengoena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karsten Koenig (Prof.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 550 014
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Brooke Alasya (Ms.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 402 200
Address
Via Universita 4
41121 Modena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alberto Giannetti (Prof.)
TP21 GMBH
Germany
EU contribution
€ 237 400
Address
Luisenstrasse 14
10117 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Petra Zalud (Dr.)
KIBERO
Germany
EU contribution
€ 262 199
Address
Bismarckstrasse 56
66121 Saarbruecken
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eike Christian Weiss (Mr.)