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IBD: proteases offer new targets for drug discovery

Objective

The inflammatory bowel diseases (IBD) which comprise Crohn’s disease and ulcerative colitis are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract. The frequency of these conditions has increased in recent decades, particularly in countries making the transition from developing to developed nation status. In western Europe, IBD now affects between 1/1000 and 5/1000 of the population, and the prevalence of the conditions in new EU accession countries appears to be growing as they develop. Few conditions in all of clinical medicine are linked with as much morbidity and potential mortality as IBD. Current treatment is based upon steroid therapy or neutralizing the effect of pro-inflammatory cytokines, especially TNFalpha. Despite their efficacy, many patients eventually require surgery for refractory disease or complications (stricture, perforation, abscess). In response to the call we have assembled a multidisciplinary team of international experts to delineate the role of intestinal proteases and their inhibitors in the pathophysiology of IBD. A particularly innovative aspect of our approach is the examination of both bacterial and host derived proteases and interactions between the two. The ultimate aim is develop novel therapeutics and increased understanding of the disease both of which will impact within the wider EU community and globally.

Field of science

  • /medical and health sciences/clinical medicine
  • /medical and health sciences/clinical medicine/gastroenterology/inflammatory bowel disease

Call for proposal

FP7-HEALTH-2007-A
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE UNIVERSITY OF SHEFFIELD
Address
Firth Court Western Bank
S10 2TN Sheffield
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 378 582
Administrative Contact
Joanne Watson (Ms.)

Participants (11)

QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 386 376
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colleen Colechin (Ms.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 250 188
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rachel Green (Ms.)
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 148 200
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francesco Pallone (Profe)
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 594 800
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ulrike Ronchetti (Ms.)
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
EU contribution
€ 93 000
Address
Videnska 1083
142 00 Praha 4
Activity type
Research Organisations
Administrative Contact
Martin Bilej (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 358 605
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Bessems (Mr.)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Steve Sheldon (Mr.)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 112 200
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mary Cusack (Ms.)
ALIMENTARY HEALTH LTD
Ireland
EU contribution
€ 195 000
Address
Kinsale Road Building 2800 Cork Airport Business Park
N/A Passage West, Co. Cork
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Brian Barrett (Dr.)
THE UNIVERSITY OF AUCKLAND
New Zealand
EU contribution
€ 107 463
Address
Princes Street 24
1010 Auckland
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lyn Clark (Ms.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 374 836
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Enck (Prof.)