Objective The inflammatory bowel diseases (IBD) which comprise Crohn’s disease and ulcerative colitis are chronic relapsing and remitting inflammatory disorders of the gastrointestinal tract. The frequency of these conditions has increased in recent decades, particularly in countries making the transition from developing to developed nation status. In western Europe, IBD now affects between 1/1000 and 5/1000 of the population, and the prevalence of the conditions in new EU accession countries appears to be growing as they develop. Few conditions in all of clinical medicine are linked with as much morbidity and potential mortality as IBD. Current treatment is based upon steroid therapy or neutralizing the effect of pro-inflammatory cytokines, especially TNFalpha. Despite their efficacy, many patients eventually require surgery for refractory disease or complications (stricture, perforation, abscess). In response to the call we have assembled a multidisciplinary team of international experts to delineate the role of intestinal proteases and their inhibitors in the pathophysiology of IBD. A particularly innovative aspect of our approach is the examination of both bacterial and host derived proteases and interactions between the two. The ultimate aim is develop novel therapeutics and increased understanding of the disease both of which will impact within the wider EU community and globally. Fields of science medical and health sciencesclinical medicinegastroenterologyinflammatory bowel diseasemedical and health sciencesclinical medicine Keywords IBD colon microflora mucosa neuro-immune function polymorphisms protease activated receptors proteases Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.4.5-2 - Inflammatory bowel disease Call for proposal FP7-HEALTH-2007-A See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator THE UNIVERSITY OF SHEFFIELD Address Firth court western bank S10 2TN Sheffield United Kingdom See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Administrative Contact Joanne Watson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all QUEEN MARY UNIVERSITY OF LONDON United Kingdom EU contribution € 386 376,00 Address 327 mile end road E1 4NS London See on map Region London Inner London — East Tower Hamlets Activity type Higher or Secondary Education Establishments Administrative Contact Colleen Colechin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF SOUTHAMPTON United Kingdom EU contribution € 250 188,00 Address Highfield SO17 1BJ Southampton See on map Region South East (England) Hampshire and Isle of Wight Southampton Activity type Higher or Secondary Education Establishments Administrative Contact Rachel Green (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy EU contribution € 148 200,00 Address Via cracovia 50 00133 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Administrative Contact Francesco Pallone (Profe) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TECHNISCHE UNIVERSITAET MUENCHEN Germany EU contribution € 594 800,00 Address Arcisstrasse 21 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Ulrike Ronchetti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MIKROBIOLOGICKY USTAV AV CR V.V.I Czechia EU contribution € 93 000,00 Address Videnska 1083 142 00 Praha 4 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Administrative Contact Martin Bilej (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 358 605,00 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Paul Bessems (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. United Kingdom EU contribution € 0,00 Address Great west road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Steve Sheldon (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Ireland EU contribution € 112 200,00 Address Western road T12 YN60 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Administrative Contact Mary Cusack (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ALIMENTARY HEALTH LTD Ireland EU contribution € 195 000,00 Address Kinsale road building 2800 cork airport business park N/A Cork See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Brian Barrett (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF AUCKLAND New Zealand EU contribution € 107 463,00 Address Princes street 24 1010 Auckland See on map Activity type Higher or Secondary Education Establishments Administrative Contact Lyn Clark (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 374 836,00 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Paul Enck (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
